Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as Inflammatory Indicators in Systemic Lupus Erythematosus Nephritis

• Published in: Archives of rheumatology 2017-03, Vol.32 (1), p.21-25
• Main Authors: Ayna, Ata Bora, Ermurat, Selime, Coskun, Belkis Nihan, Harman, Halil, Pehlvan, Yavuz
• Format: Article
• Language: English
• Subjects: Blood; C-reactive protein; Lupus; Lymphocytes; Medical examination; Medical records; Medical research; Medicine, Experimental; Nephritis; Systemic lupus erythematosus
• ISSN: 2148-5046
• DOI: 10.5606/ArchRheumatol.2017.5886

Objectives: This study aims to evaluate the role of neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) as activation and inflammatory markers in systemic lupus erythematosus (SLE) patients with nephritis. Patients and methods: A total of 108 SLE patients (8 males, 100 females; mean age 35.3 [+ or -] 10.2 years; range 16 to 64 years) including 78 patients with renal involvement (8 males, 70 females; mean age 33.9 [+ or -] 10.6 years; range 16 to 64 years) (SLEn+ group) and 30 patients without renal involvement (30 females; mean age 39.1 [+ or -] 8.2 years; range 22 to 55 years) (SLEn- group) were included in this retrospective study. All patients' clinical characteristics and laboratory data which include erythrocyte sedimentation rate, C-reactive protein, white blood counts, neutrophil counts, lymphocyte counts, platelet counts, and MPV levels were obtained from medical records. The laboratory data at the highest proteinuria periods of the patients with renal involvement were recorded. Results: Mean MPV (SLEn+ =9.1 [+ or -] 2.2, SLEn- =7.9 [+ or -] 1.2, p=0.001) and NLR (SLEn+ =5.9 [+ or -] 5.9, SLEn- =2.6 [+ or -] 2.5, p