Quantitative second harmonic generation microscopy for the structural characterization of capsular collagen in thyroid neoplasms

Quantitative second harmonic generation microscopy was used to investigate collagen organization in the fibrillar capsules of human benign and malignant thyroid nodules. We demonstrate that the combination of texture analysis and second harmonic generation images of collagen can be used to different...

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Bibliographic Details
Published in:Biomedical optics express 2018-08, Vol.9 (8), p.3923-3936
Main Authors: Hristu, Radu, Eftimie, Lucian G, Stanciu, Stefan G, Tranca, Denis E, Paun, Bogdan, Sajin, Maria, Stanciu, George A
Format: Article
Language:English
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Summary:Quantitative second harmonic generation microscopy was used to investigate collagen organization in the fibrillar capsules of human benign and malignant thyroid nodules. We demonstrate that the combination of texture analysis and second harmonic generation images of collagen can be used to differentiate between capsules surrounding the thyroid follicular adenoma and papillary carcinoma nodules. Our findings indicate that second harmonic generation microscopy can provide quantitative information about the collagenous capsule surrounding both the thyroid and thyroid nodules, which may complement traditional histopathological examination.
ISSN:2156-7085
2156-7085
DOI:10.1364/boe.9.003923