Association between circulating tumor necrosis factor-related biomarkers and estimated glomerular filtration rate in type 2 diabetes

• Published in: Scientific reports 2018-10, Vol.8 (1), p.15302-7, Article 15302
• Main Authors: Kamei, Nozomu, Yamashita, Mami, Nishizaki, Yuji, Yanagisawa, Naotake, Nojiri, Shuko, Tanaka, Kanako, Yamashita, Yoshinori, Shibata, Terumi, Murakoshi, Maki, Suzuki, Yusuke, Gohda, Tomohito
• Format: Article
• Language: English
• Subjects: 692/163/2743/137/773; 692/4022/1585; Biomarkers; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Epidermal growth factor receptors; Glomerular filtration rate; Humanities and Social Sciences; multidisciplinary; Necrosis; Receptor mechanisms; Renal function; Risk factors; Science; Science (multidisciplinary); Tumor necrosis factor receptors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Uric acid
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-33590-w

Chronic inflammation plays a crucial role in the development/progression of diabetic kidney disease. The involvement of tumor necrosis factor (TNF)-related biomarkers [TNFα, progranulin (PGRN), TNF receptors (TNFR1 and TNFR2)] and uric acid (UA) in renal function decline was investigated in patients with type 2 diabetes (T2D). Serum TNF-related biomarkers and UA levels were measured in 594 Japanese patients with T2D and an eGFR ≥30 mL/min/1.73 m 2 . Four TNF-related biomarkers and UA were negatively associated with estimated glomerular filtration rate (eGFR). In a logistic multivariate model, each TNF-related biomarker and UA was associated with lower eGFR (eGFR