A Retrospective Study on the Risk of Respiratory Distress Syndrome in Singleton Pregnancies with Preterm Premature Rupture of Membranes between 24+0 and 36+6 Weeks, Using Regression Analysis for Various Factors

• Published in: BioMed research international 2018-01, Vol.2018 (2018), p.1-6
• Main Authors: Dąbrowski, Krzysztof, Skrzypulec-Plinta, Wioletta, Wloch, Agata, Borowski, Dariusz, Węgrzyn, Piotr, Kierach, Rafał, Wójtowicz, Dominik, Jagielska, Agnieszka, Ciaciura-Jarno, Magdalena, Ruci, Aleksandra, Czuba, Bartosz, Cnota, Wojciech, Niesłuchowska-Hoxha, Anna, Sidorowicz, Marcin
• Format: Article
• Language: English
• Subjects: Adult; Age; Androgens; Anemia; Apgar score; Archives & records; Complications; Congenital diseases; Diabetes mellitus; Disease; Endocrinology; Female; Fetal Membranes, Premature Rupture - epidemiology; Fetal Membranes, Premature Rupture - etiology; Fetal Membranes, Premature Rupture - physiopathology; Fetuses; Gender differences; Gene expression; Gestational age; Glucose tolerance; Gynecology; Heart rate; Hemoglobin; Humans; Hypertension; Infants; Infants (Newborn); Infections; Intolerance; Latency; Lungs; Medical research; Medicine, Experimental; Membranes; Metabolism; Neonates; Obstetrics; Parameters; Pathogenesis; Pregnancy; Pregnancy complications; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Pregnant women; Premature birth; Premature rupture of membranes; Pulmonary arteries; Regression analysis; Respiration; Respiratory distress syndrome; Respiratory Distress Syndrome, Newborn - epidemiology; Respiratory Distress Syndrome, Newborn - etiology; Respiratory Distress Syndrome, Newborn - physiopathology; Respiratory therapy; Retrospective Studies; Risk analysis; Risk Factors; Rupture; Rupturing; Steroid hormones; Steroids; Surfactants; Veins & arteries; Weight
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2018/7162478

Aim. This study aimed to investigate the cause of respiratory distress syndrome (RDS) in neonates from singleton pregnancies with preterm premature rupture of membranes (pPROM) between 24+0 and 36+6 weeks by using regression analysis for various factors. Methods. In 175 singleton pregnancies with pPROM, 95 cases of RDS (54,29%) were diagnosed. In all cases the following information was collected: latency period of PROM, gestational age at birth, Umbilical Artery Pulsatility Index (UA PI), Middle Cerebral Artery Pulsatility Index (MCA PI), fetal distress, antenatal steroids use, delivery type, pregnancy hypertension disease, gestational glucose intolerance or diabetes, neonatal laboratory parameters, gender, weight, Apgar score, and other neonatal complications. Logistic regression analysis was used to investigate the effect of variables on RDS. Results. The results of logistic regression analysis showed that the following variables are closely correlated with RDS: female gender (OR=0.52; 95%CI:0.28-0,97), antenatal steroids use (OR=0,46; 95%CI:0,34-0,64), abnormal UA PI and MCA PI (OR=2.96; 95%CI:1,43-6,12) (OR=2.05; 95%CI:1,07-3,95), fetal distress (OR=2.33; 95%CI:1,16-4,71), maternal HGB (OR=0.69; 95%CI:0,5-0,96), and neonatal RBC, HGB (OR=0.32; 95%CI:0,19-0,55) (OR=0.75; 95%CI:0,65-0,88). Conclusions. The main RDS risk factors in premature neonates are gender, abnormal fetoplacental circulation, and fetal distress. The laboratory parameters such as lower RBC and HGB count are observed in infants with RDS.