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Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens

Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, w...

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Bibliographic Details
Published in:Scientific reports 2018-10, Vol.8 (1), p.15417-9, Article 15417
Main Authors: Chao, Chih-Hua, Cheng, Ju-Chien, Gonçalves, Théo P., Huang, Kuo-Wei, Lin, Chi-Chien, Huang, Hui-Chi, Hwang, Syh-Yuan, Wu, Yang-Chang
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Language:English
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Summary:Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-33748-6