Alendronate release from calcium phosphate cement for bone regeneration in osteoporotic conditions

Osteoporosis represents a major health problem in terms of compromising bone strength and increasing the risk of bone fractures. It can be medically treated with bisphosphonates, which act systemically upon oral or venous administration. Further, bone regenerative treatments in osteoporotic conditio...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2018-10, Vol.8 (1), p.15398-13, Article 15398
Main Authors: van Houdt, Claire I. A., Gabbai-Armelin, Paulo R., Lopez-Perez, Paula M., Ulrich, Dietmar J. O., Jansen, John A., Renno, Ana Claudia M., van den Beucken, Jeroen J. J. P.
Format: Article
Language:English
Subjects:
13/107
14/32
14/63
631/1647/767/2200
639/301/54/152
692/699/317/821
Alendronic acid
Bisphosphonates
Bone growth
Bone strength
Calcium phosphates
Cement
Controlled release
Femur
Fractures
Glycolic acid
Humanities and Social Sciences
multidisciplinary
Osteogenesis
Osteoporosis
Polylactide-co-glycolide
Regeneration
Science
Science (multidisciplinary)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Osteoporosis represents a major health problem in terms of compromising bone strength and increasing the risk of bone fractures. It can be medically treated with bisphosphonates, which act systemically upon oral or venous administration. Further, bone regenerative treatments in osteoporotic conditions present a challenge. Here, we focused on the development of a synthetic bone substitute material with local diminishing effects on osteoporosis. Composites were created using calcium phosphate cement (CPC; 60 wt%) and polylactic-co-glycolic acid (PLGA; 40 wt%), which were loaded with alendronate (ALN). In vitro results showed that ALN-loaded CPC/PLGA composites presented clinically suitable properties, including setting times, appropriate compressive strength, and controlled release of ALN, the latter being dependent on composite degradation. Using a rat femoral condyle bone defect model in osteoporotic animals, ALN-loaded CPC/PLGA composites demonstrated stimulatory effects on bone formation both within and outside the defect region.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-33692-5