High-Sensitivity cardiac Troponins in Cardio-Healthy Subjects: A Cardiovascular Magnetic Resonance Imaging Study

The 99 th percentile upper reference limits (URL) of high-sensitivity cardiac troponin (hs-cTn) in healthy subjects are essential for diagnosis and management of cardiovascular diseases. Unless screened stringently, subclinical disease affects the derived URL. In 779 healthy subjects(49% males; 17–8...

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Bibliographic Details
Published in:Scientific reports 2018-10, Vol.8 (1), p.1-11, Article 15409
Main Authors: Aw, Tar-Choon, Huang, Wei-ting, Le, Thu-Thao, Pua, Chee-Jian, Ang, Briana, Phua, Soon-Kieng, Yeo, Khung-Keong, Cook, Stuart A., Chin, Calvin W. L.
Format: Article
Language:English
Subjects:
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Age
Biomarkers
Blood pressure
Calcium-binding protein
Cardiovascular diseases
Diabetes
Epidermal growth factor receptors
Glomerular filtration rate
Humanities and Social Sciences
Kidney diseases
Magnetic resonance imaging
Males
Morphology
multidisciplinary
Questionnaires
Science
Science (multidisciplinary)
Troponin
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Summary:The 99 th percentile upper reference limits (URL) of high-sensitivity cardiac troponin (hs-cTn) in healthy subjects are essential for diagnosis and management of cardiovascular diseases. Unless screened stringently, subclinical disease affects the derived URL. In 779 healthy subjects(49% males; 17–88 years) screened by cardiovascular magnetic resonance (CMR), the gold standard for assessing cardiac volumes and myocardial mass; and estimated glomerular filtration rate (eGFR), the 99 th percentile URL of hsTnT (Roche) and hs-cTnI (Abbott) were similar to the published URL. The overall 99 th percentile URL of hsTnT and hsTnI were 15.2 and 21.2 ng/L, respectively; males had higher values than females (hsTnT: 16.8 versus 11.9 ng/L and hsTnI: 38.8 versus 14.4 ng/L). Correlation between hsTnT and hsTnI was modest (r = 0.45; p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-33850-9