Association Between - 675 ID, 4G/5G PAI-1 Gene Polymorphism and Pregnancy Loss: A Systematic Review

Several analysis for different population conclude that endothelial plasminogen activator inhibitor 1 gene polymorphism, -675 ID, 4G/5G (ref SNP ID: rs1799889, also described as rs34857375, has merged into rs1799762) may increase risk of pregnancy loss (PL). However, there is a disagreement as to th...

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Bibliographic Details
Published in:Acta informatica medica 2018-10, Vol.26 (3), p.156-159
Main Authors: Adler, Grazyna, Mahmutbegovic, Emir, Valjevac, Amina, Adler, Mateusz A, Mahmutbegovic, Nevena, Safranow, Krzysztof, Czerska, Ewa, Pawinska-Matecka, Anna, Ciechanowicz, Iwona, Marjanovic, Damir
Format: Article
Language:English
Subjects:
Literature reviews
Miscarriage
Original Paper
Polymorphism
Populations
Pregnancy
Systematic review
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Summary:Several analysis for different population conclude that endothelial plasminogen activator inhibitor 1 gene polymorphism, -675 ID, 4G/5G (ref SNP ID: rs1799889, also described as rs34857375, has merged into rs1799762) may increase risk of pregnancy loss (PL). However, there is a disagreement as to the association 4G allele with pregnancy loss. Therefore, we decided to investigate the -675 ID, 4G/5G as a potential genetic factor linked to PL in European and worldwide populations. A systematic review of the scientific literature was conducted with the use of the PubMed and Scopus electronic databases (1991-present), using the following search terms: pregnancy loss, miscarriage, genetic risk of thrombophilia, rs1799889 -1 gen, 4G/5G gene polymorphism, gene locus 4G/5G polymorphism. Among European populations, the statistically significant association between 4G allele and recurrent PL only in Czechs and Bulgarian women was found (p
ISSN:0353-8109
1986-5988
DOI:10.5455/aim.2018.26.156-159