An Evaluation of Clinical and Histopathological Aspects of Patients with Oral Submucous Fibrosis in the Background of Oral Squamous Cell Carcinoma

• Published in: BioMed research international 2018-01, Vol.2018 (2018), p.1-7
• Main Authors: Tilakaratne, W. M., Senarath, N. H., Jayawardena, K. L. T. D., Siriwardena, B. S. M. S.
• Format: Article
• Language: English
• Subjects: Age; Alcohol; Alcohols; Archives & records; Buccal mucosa; Carcinoma, Squamous Cell - pathology; Chewing; Demographics; Differentiation; Evaluation; Extracellular matrix; Feature extraction; Female; Fibrosis; Humans; Hypoxia; Lymph nodes; Lymphatic system; Male; Mastication; Metastases; Metastasis; Middle Aged; Mouth Neoplasms - pathology; Neoplasm Metastasis; Oral cancer; Oral Hygiene; Oral squamous cell carcinoma; Oral Submucous Fibrosis - pathology; Pathology; Patients; Prognosis; Smoking; Squamous cell carcinoma; Studies; Tumors
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2018/4154165

Background. The behavior and prognosis of oral squamous cell carcinoma (OSCC) is presumably different in patients with oral submucous fibrosis (OSF). The objective of this study was to assess the effects of demographic features, habits, and histopathological features in the transformation of OSF to OSCC. Methods. Data were extracted from the archives and histopathological evaluation and presence of nodal metastasis were recorded. Results. OSF was detected in 130 (48%) out of 273 OSCC patients. The mean age of presentation among OSF-positive patients was 57.7 years, while patients diagnosed only with OSCC had a comparatively higher age, 59.5 years. In the below 50 years of age group, presence of OSF with OSCC was less (40%). In the OSF-positive group, male to female ratio was 3.2:1. The common primary sites were buccal mucosa and tongue in both groups. Betel quid chewing was present in more than 95% of the sample. Betel chewing, smoking, and alcohol consumption were present in 26.15% of OSF-positive patients. Degree of fibrosis was neither associated with the level of histological differentiation of the tumor (p= 0.195) nor associated with the malignant transformation (p =0.373). Lymph node metastasis was not seen in 76.63% and 68.54% of the patients with and without OSF, respectively. Conclusions. High degree of prevalence of OSF was observed among the OSCC patients. There were also a male predilection and younger age at presentation in these patients. However, a significant association was not observed in the degree of fibrosis with malignant transformation or the level of histopathological differentiation of the tumor. Lymph node metastasis also failed to express a significant relationship with the presence of OSF.