Genetic polymorphisms in CDH1 are associated with endometrial carcinoma susceptibility among Chinese Han women

The cadherin 1 ( ) gene plays critical roles in the epithelial-mesenchymal transition process, potentially offering us a glimpse into the development of endometrial carcinoma (EC). The present study aimed to identify whether genetic variants in affect EC susceptibility in Chinese Han women, using a...

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Bibliographic Details
Published in:Oncology letters 2018-11, Vol.16 (5), p.6868-6878
Main Authors: Geng, Yue-Hang, Wang, Zi-Fan, Jia, Yu-Mian, Zheng, Li-Yuan, Chen, Lan, Liu, Dong-Ge, Li, Xiang-Hong, Tian, Xin-Xia, Fang, Wei-Gang
Format: Article
Language:English
Subjects:
Body mass index
Endometrial cancer
Mutation
Womens health
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Summary:The cadherin 1 ( ) gene plays critical roles in the epithelial-mesenchymal transition process, potentially offering us a glimpse into the development of endometrial carcinoma (EC). The present study aimed to identify whether genetic variants in affect EC susceptibility in Chinese Han women, using a strategy combining haplotype-tagging single nucleotide polymorphisms (htSNPs) association analysis with fine-scale mapping. A total of 9 htSNPs in were genotyped among 516 cases and 706 age-matched cancer-free controls. Logistic regression analyses revealed 3 htSNPs (rs17715799, rs6499199 and rs13689) to be associated with increased EC risk and 3 htSNPs (rs12185157, rs10431923 and rs4783689) with decreased EC risk. Furthermore, 14 newly imputed SNPs of were identified to be associated with EC risk (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.9469