Analysis of urinary macrophage migration inhibitory factor in systemic lupus erythematosus

ObjectiveTo characterise the clinical relevance of urinary macrophage migration inhibitory factor (uMIF) concentrations in patients with systemic lupus erythematosus (SLE).MethodsMIF, adjusted for urine creatinine, was quantified by ELISA in urine samples from 64 prospectively recruited patients wit...

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Bibliographic Details
Published in:Lupus science & medicine 2018-01, Vol.5 (1), p.e000277-e000277
Main Authors: Vincent, Fabien B, Slavin, Laura, Hoi, Alberta Y, Kitching, Arthur Richard, Mackay, Fabienne, Harris, James, Kandane-Rathnayake, Rangi, Morand, Eric F
Format: Article
Language:English
Subjects:
Arthritis
Biomarker Studies
Biomarkers
Chemokines
Classification
Kidney diseases
Ligands
Lupus
Migration
Pathogenesis
Regression analysis
Statistical analysis
Tumor necrosis factor-TNF
Urine
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Summary:ObjectiveTo characterise the clinical relevance of urinary macrophage migration inhibitory factor (uMIF) concentrations in patients with systemic lupus erythematosus (SLE).MethodsMIF, adjusted for urine creatinine, was quantified by ELISA in urine samples from 64 prospectively recruited patients with SLE. Serum MIF and urinary monocyte chemoattractant protein 1 (uMCP-1) were quantified by ELISA in a subset of patients (n = 39). Disease activity was assessed using the SLE Disease Activity Index-2000 (SLEDAI-2K) score.ResultsuMIF was detectable in all patients with SLE. uMIF was positively correlated with overall SLEDAI-2K, was significantly higher in patients with SLE with high disease activity (SLEDAI-2K≥10) compared with those with inactive disease (SLEDAI-2K
ISSN:2053-8790
2053-8790
DOI:10.1136/lupus-2018-000277