Analysis of urinary macrophage migration inhibitory factor in systemic lupus erythematosus

ObjectiveTo characterise the clinical relevance of urinary macrophage migration inhibitory factor (uMIF) concentrations in patients with systemic lupus erythematosus (SLE).MethodsMIF, adjusted for urine creatinine, was quantified by ELISA in urine samples from 64 prospectively recruited patients wit...

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Published in:Lupus science & medicine 2018-01, Vol.5 (1), p.e000277-e000277
Main Authors: Vincent, Fabien B, Slavin, Laura, Hoi, Alberta Y, Kitching, Arthur Richard, Mackay, Fabienne, Harris, James, Kandane-Rathnayake, Rangi, Morand, Eric F
Format: Article
Language:English
Subjects:
Arthritis
Biomarker Studies
Biomarkers
Chemokines
Classification
Kidney diseases
Ligands
Lupus
Migration
Pathogenesis
Regression analysis
Statistical analysis
Tumor necrosis factor-TNF
Urine
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container_title Lupus science & medicine
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Slavin, Laura
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description ObjectiveTo characterise the clinical relevance of urinary macrophage migration inhibitory factor (uMIF) concentrations in patients with systemic lupus erythematosus (SLE).MethodsMIF, adjusted for urine creatinine, was quantified by ELISA in urine samples from 64 prospectively recruited patients with SLE. Serum MIF and urinary monocyte chemoattractant protein 1 (uMCP-1) were quantified by ELISA in a subset of patients (n = 39). Disease activity was assessed using the SLE Disease Activity Index-2000 (SLEDAI-2K) score.ResultsuMIF was detectable in all patients with SLE. uMIF was positively correlated with overall SLEDAI-2K, was significantly higher in patients with SLE with high disease activity (SLEDAI-2K≥10) compared with those with inactive disease (SLEDAI-2K
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Serum MIF and urinary monocyte chemoattractant protein 1 (uMCP-1) were quantified by ELISA in a subset of patients (n = 39). Disease activity was assessed using the SLE Disease Activity Index-2000 (SLEDAI-2K) score.ResultsuMIF was detectable in all patients with SLE. uMIF was positively correlated with overall SLEDAI-2K, was significantly higher in patients with SLE with high disease activity (SLEDAI-2K≥10) compared with those with inactive disease (SLEDAI-2K&lt;4), and this association remained significant after adjusting for ethnicity, flare and use of immunosuppressants. uMIF was also significantly higher in SLE patients with flare of disease, although not confirmed in multivariable analysis. No significant differences in uMIF levels were observed according to the presence of renal disease activity, as assessed by renal SLEDAI-2K or biopsy-confirmed lupus nephritis. In contrast, uMCP-1 was significantly higher in SLE patients with active renal disease. uMIF expression was not associated with irreversible organ damage accrual or glucocorticoid use.ConclusionsThese data suggest uMIF as a potential overall but not renal-specific SLE biomarker, whereas uMCP-1 is a renal-specific SLE biomarker.</description><identifier>ISSN: 2053-8790</identifier><identifier>EISSN: 2053-8790</identifier><identifier>DOI: 10.1136/lupus-2018-000277</identifier><identifier>PMID: 30397495</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Arthritis ; Biomarker Studies ; Biomarkers ; Chemokines ; Classification ; Kidney diseases ; Ligands ; Lupus ; Migration ; Pathogenesis ; Regression analysis ; Statistical analysis ; Tumor necrosis factor-TNF ; Urine</subject><ispartof>Lupus science &amp; medicine, 2018-01, Vol.5 (1), p.e000277-e000277</ispartof><rights>Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2018 Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b464t-b9b0b9a9b7b12bf7339ce9e120dfad4abdc79ac89a8d4cf990a601fd04ecb42e3</citedby><cites>FETCH-LOGICAL-b464t-b9b0b9a9b7b12bf7339ce9e120dfad4abdc79ac89a8d4cf990a601fd04ecb42e3</cites><orcidid>0000-0001-7220-0800</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2124677713/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2124677713?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27548,27549,27923,27924,37011,37012,44589,53790,53792,74997,77472,77503</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30397495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vincent, Fabien B</creatorcontrib><creatorcontrib>Slavin, Laura</creatorcontrib><creatorcontrib>Hoi, Alberta Y</creatorcontrib><creatorcontrib>Kitching, Arthur Richard</creatorcontrib><creatorcontrib>Mackay, Fabienne</creatorcontrib><creatorcontrib>Harris, James</creatorcontrib><creatorcontrib>Kandane-Rathnayake, Rangi</creatorcontrib><creatorcontrib>Morand, Eric F</creatorcontrib><title>Analysis of urinary macrophage migration inhibitory factor in systemic lupus erythematosus</title><title>Lupus science &amp; medicine</title><addtitle>Lupus Sci Med</addtitle><description>ObjectiveTo characterise the clinical relevance of urinary macrophage migration inhibitory factor (uMIF) concentrations in patients with systemic lupus erythematosus (SLE).MethodsMIF, adjusted for urine creatinine, was quantified by ELISA in urine samples from 64 prospectively recruited patients with SLE. Serum MIF and urinary monocyte chemoattractant protein 1 (uMCP-1) were quantified by ELISA in a subset of patients (n = 39). Disease activity was assessed using the SLE Disease Activity Index-2000 (SLEDAI-2K) score.ResultsuMIF was detectable in all patients with SLE. uMIF was positively correlated with overall SLEDAI-2K, was significantly higher in patients with SLE with high disease activity (SLEDAI-2K≥10) compared with those with inactive disease (SLEDAI-2K&lt;4), and this association remained significant after adjusting for ethnicity, flare and use of immunosuppressants. uMIF was also significantly higher in SLE patients with flare of disease, although not confirmed in multivariable analysis. No significant differences in uMIF levels were observed according to the presence of renal disease activity, as assessed by renal SLEDAI-2K or biopsy-confirmed lupus nephritis. In contrast, uMCP-1 was significantly higher in SLE patients with active renal disease. uMIF expression was not associated with irreversible organ damage accrual or glucocorticoid use.ConclusionsThese data suggest uMIF as a potential overall but not renal-specific SLE biomarker, whereas uMCP-1 is a renal-specific SLE biomarker.</description><subject>Arthritis</subject><subject>Biomarker Studies</subject><subject>Biomarkers</subject><subject>Chemokines</subject><subject>Classification</subject><subject>Kidney diseases</subject><subject>Ligands</subject><subject>Lupus</subject><subject>Migration</subject><subject>Pathogenesis</subject><subject>Regression analysis</subject><subject>Statistical analysis</subject><subject>Tumor necrosis factor-TNF</subject><subject>Urine</subject><issn>2053-8790</issn><issn>2053-8790</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>PIMPY</sourceid><recordid>eNqNkU1rGzEQhkVJqU2aH5BLWeglh247-vBqdQmYkH6AIZfmkosYabW2zO7KlXYD_veR4ySkOeU0QvPMy8z7EnJO4TulvPrRTbsplQxoXQIAk_IDmTNY8LKWCk5evWfkLKVtZiijXNbwicw4cCWFWszJ3XLAbp98KkJbTNEPGPdFjzaG3QbXruj9OuLow1D4YeONH0Put2hzzT9F2qfR9d4Wj9sULu7HjetxDGlKn8nHFrvkzp7qKbn9ef336ne5uvn152q5Ko2oxFgaZcAoVEYaykwrOVfWKUcZNC02Ak1jpUJbK6wbYVulACugbQPCWSOY46fk8qi7m0zvGuuGMWKnd9H3-Rgd0Ov_O4Pf6HW41xUDDoJlgYsngRj-TS6NuvfJuq7DwYUp6WxbBvmCH9Cvb9BtmGK28EAxUUkpKc8UPVLZxpSia1-WoaAP4elHu_QhPH0ML898eX3Fy8RzVBn4dgRMv32H3gP66KgA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Vincent, Fabien B</creator><creator>Slavin, Laura</creator><creator>Hoi, Alberta Y</creator><creator>Kitching, Arthur Richard</creator><creator>Mackay, Fabienne</creator><creator>Harris, James</creator><creator>Kandane-Rathnayake, Rangi</creator><creator>Morand, Eric F</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7220-0800</orcidid></search><sort><creationdate>20180101</creationdate><title>Analysis of urinary macrophage migration inhibitory factor in systemic lupus erythematosus</title><author>Vincent, Fabien B ; Slavin, Laura ; Hoi, Alberta Y ; Kitching, Arthur Richard ; Mackay, Fabienne ; Harris, James ; Kandane-Rathnayake, Rangi ; Morand, Eric F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b464t-b9b0b9a9b7b12bf7339ce9e120dfad4abdc79ac89a8d4cf990a601fd04ecb42e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Arthritis</topic><topic>Biomarker Studies</topic><topic>Biomarkers</topic><topic>Chemokines</topic><topic>Classification</topic><topic>Kidney diseases</topic><topic>Ligands</topic><topic>Lupus</topic><topic>Migration</topic><topic>Pathogenesis</topic><topic>Regression analysis</topic><topic>Statistical analysis</topic><topic>Tumor necrosis factor-TNF</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vincent, Fabien B</creatorcontrib><creatorcontrib>Slavin, Laura</creatorcontrib><creatorcontrib>Hoi, Alberta Y</creatorcontrib><creatorcontrib>Kitching, Arthur Richard</creatorcontrib><creatorcontrib>Mackay, Fabienne</creatorcontrib><creatorcontrib>Harris, James</creatorcontrib><creatorcontrib>Kandane-Rathnayake, Rangi</creatorcontrib><creatorcontrib>Morand, Eric F</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; 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medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vincent, Fabien B</au><au>Slavin, Laura</au><au>Hoi, Alberta Y</au><au>Kitching, Arthur Richard</au><au>Mackay, Fabienne</au><au>Harris, James</au><au>Kandane-Rathnayake, Rangi</au><au>Morand, Eric F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of urinary macrophage migration inhibitory factor in systemic lupus erythematosus</atitle><jtitle>Lupus science &amp; medicine</jtitle><addtitle>Lupus Sci Med</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>5</volume><issue>1</issue><spage>e000277</spage><epage>e000277</epage><pages>e000277-e000277</pages><issn>2053-8790</issn><eissn>2053-8790</eissn><abstract>ObjectiveTo characterise the clinical relevance of urinary macrophage migration inhibitory factor (uMIF) concentrations in patients with systemic lupus erythematosus (SLE).MethodsMIF, adjusted for urine creatinine, was quantified by ELISA in urine samples from 64 prospectively recruited patients with SLE. Serum MIF and urinary monocyte chemoattractant protein 1 (uMCP-1) were quantified by ELISA in a subset of patients (n = 39). Disease activity was assessed using the SLE Disease Activity Index-2000 (SLEDAI-2K) score.ResultsuMIF was detectable in all patients with SLE. uMIF was positively correlated with overall SLEDAI-2K, was significantly higher in patients with SLE with high disease activity (SLEDAI-2K≥10) compared with those with inactive disease (SLEDAI-2K&lt;4), and this association remained significant after adjusting for ethnicity, flare and use of immunosuppressants. uMIF was also significantly higher in SLE patients with flare of disease, although not confirmed in multivariable analysis. No significant differences in uMIF levels were observed according to the presence of renal disease activity, as assessed by renal SLEDAI-2K or biopsy-confirmed lupus nephritis. In contrast, uMCP-1 was significantly higher in SLE patients with active renal disease. uMIF expression was not associated with irreversible organ damage accrual or glucocorticoid use.ConclusionsThese data suggest uMIF as a potential overall but not renal-specific SLE biomarker, whereas uMCP-1 is a renal-specific SLE biomarker.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>30397495</pmid><doi>10.1136/lupus-2018-000277</doi><orcidid>https://orcid.org/0000-0001-7220-0800</orcidid><oa>free_for_read</oa></addata></record>
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subjects Arthritis
Biomarker Studies
Biomarkers
Chemokines
Classification
Kidney diseases
Ligands
Lupus
Migration
Pathogenesis
Regression analysis
Statistical analysis
Tumor necrosis factor-TNF
Urine
title Analysis of urinary macrophage migration inhibitory factor in systemic lupus erythematosus
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