Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B–E, 2–5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits b...

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Bibliographic Details
Published in:Organic letters 2017-11, Vol.19 (22), p.6192-6195
Main Authors: Yan, Xiaohui, Chen, Jian-Jun, Adhikari, Ajeeth, Yang, Dong, Crnovcic, Ivana, Wang, Nan, Chang, Chin-Yuan, Rader, Christoph, Shen, Ben
Format: Article
Language:English
Subjects:
Anthraquinones
Enediynes
Genome, Bacterial
Humans
Micromonospora
Molecular Structure
Multigene Family
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Summary:A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B–E, 2–5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody–drug conjugates.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b03120