Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B–E, 2–5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits b...

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Published in:Organic letters 2017-11, Vol.19 (22), p.6192-6195
Main Authors: Yan, Xiaohui, Chen, Jian-Jun, Adhikari, Ajeeth, Yang, Dong, Crnovcic, Ivana, Wang, Nan, Chang, Chin-Yuan, Rader, Christoph, Shen, Ben
Format: Article
Language:English
Subjects:
Anthraquinones
Enediynes
Genome, Bacterial
Humans
Micromonospora
Molecular Structure
Multigene Family
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cited_by cdi_FETCH-LOGICAL-a511t-6cba0cf6713f3654691dfb1b889dbe979cf1f01fd683b70ea0a7a99ab28360283
cites cdi_FETCH-LOGICAL-a511t-6cba0cf6713f3654691dfb1b889dbe979cf1f01fd683b70ea0a7a99ab28360283
container_end_page 6195
container_issue 22
container_start_page 6192
container_title Organic letters
container_volume 19
creator Yan, Xiaohui
Chen, Jian-Jun
Adhikari, Ajeeth
Yang, Dong
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Rader, Christoph
Shen, Ben
description A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B–E, 2–5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody–drug conjugates.
doi_str_mv 10.1021/acs.orglett.7b03120
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Anthraquinones
Enediynes
Genome, Bacterial
Humans
Micromonospora
Molecular Structure
Multigene Family
title Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne
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