Synthesis of N-Bridged Pyrido[4,3-d]pyrimidines and Self-Assembly into Twin Rosette Cages and Nanotubes in Organic Media

Two N-bridged pyrido[4,3- d ]pyrimidine derivatives were synthesized toward realization of a self-assembled bis-rosette cage, in organic media. Starting from commercially available malononitrile dimer and dimethyl 5-aminoisophthalate, the target molecules were synthesized in 11 steps using a converg...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2018-10, Vol.8 (1), p.15949-8, Article 15949
Main Authors: Igci, Cansu, Karaman, Osman, Fan, Yiwen, Gonzales, Arthur A., Fenniri, Hicham, Gunbas, Gorkem
Format: Article
Language:English
Subjects:
119/118
140/131
639/301/923/966
639/638/541/966
Acids
Chemistry
Electron microscopy
Humanities and Social Sciences
Magnetic resonance spectroscopy
Mass spectrometry
Mass spectroscopy
Molecular modelling
multidisciplinary
Nanotechnology
Nanotubes
NMR
Nuclear magnetic resonance
Pyrimidines
Scanning electron microscopy
Science
Science (multidisciplinary)
Self-assembly
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two N-bridged pyrido[4,3- d ]pyrimidine derivatives were synthesized toward realization of a self-assembled bis-rosette cage, in organic media. Starting from commercially available malononitrile dimer and dimethyl 5-aminoisophthalate, the target molecules were synthesized in 11 steps using a convergent approach. The final bridged compounds were characterized by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The hierarchical self-assembly of the nanocages into rosette nanotubes and nanobundles was established by electron microscopy and molecular modelling studies.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-34080-9