Effects of Water, Sanitation, Handwashing, and Nutritional Interventions on Child Enteric Protozoan Infections in Rural Bangladesh: A Cluster-Randomized Controlled Trial

The trial found that individual handwashing and sanitation interventions significantly reduced childhood Giardia infections. Combined interventions provided no additional benefit. To reduce Giardia infection, individual interventions may be more feasible and cost-effective than combined intervention...

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Published in:Clinical infectious diseases 2018-10, Vol.67 (10), p.1515-1522
Main Authors: Lin, Audrie, Ercumen, Ayse, Benjamin-Chung, Jade, Arnold, Benjamin F, Das, Shimul, Haque, Rashidul, Ashraf, Sania, Parvez, Sarker M, Unicomb, Leanne, Rahman, Mahbubur, Hubbard, Alan E, Stewart, Christine P, Colford, John M, Luby, Stephen P
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Language:English
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Summary:The trial found that individual handwashing and sanitation interventions significantly reduced childhood Giardia infections. Combined interventions provided no additional benefit. To reduce Giardia infection, individual interventions may be more feasible and cost-effective than combined interventions in similar rural, low-income settings. Abstract Background We evaluated effects of individual and combined water, sanitation, handwashing (WSH), and nutritional interventions on protozoan infections in children. Methods We randomized geographical clusters of pregnant women in rural Bangladesh into chlorinated drinking water, hygienic sanitation, handwashing, nutrition, combined WSH, nutrition plus WSH (N+WSH), or control arms. Participants were not masked. After approximately 2.5 years of intervention, we measured Giardia, Cryptosporidium, and Entamoeba histolytica prevalence and infection intensity by multiplex real-time polymerase chain reaction of child stool. Analysis was intention-to-treat. Results Between May 2012 and July 2013, we randomized 5551 pregnant women. At follow-up, among 4102 available women, we enrolled 6694 children into the protozoan assessment. We analyzed stool from 5933 children (aged ~31 months) for protozoan infections. Compared with 35.5% prevalence among controls, Giardia infection prevalence was lower in the sanitation (26.5%; prevalence ratio [PR], 0.75 [95% confidence interval {CI}, .64-.88]), handwashing (28.2%; PR, 0.80 [95% CI, .66-.96]), WSH (29.7%; PR, 0.83 [95% CI, .72-.96]), and N+WSH (26.7%; PR, 0.75 [95% CI, .64-.88]) arms. Water and nutrition interventions had no effect. Low prevalence of E. histolytica and Cryptosporidium (
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciy320