Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog

A large abdominal mass was found in a dog. Histopathologically, the surface of the mass was covered with compressed adrenal gland tissue. The neoplastic cells showed typical features of malignant peripheral nerve sheath tumor (MPNST), including Antoni type A and type B pattern, and nuclear palisadin...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2018, Vol.80(10), pp.1572-1575
Main Authors: ICHIKAWA, Mika, SUZUKI, Satoshi, TEI, Meina, NIBE, Kazumi, UCHIDA, Kazuyuki, ONO, Kenichiro, HIRAO, Hidehiro
Format: Article
Language:English
Subjects:
adrenal gland
Adrenal Gland Neoplasms - veterinary
Adrenal glands
Animals
dog
Dog Diseases - pathology
Dogs
Lesions
Male
malignant peripheral nerve sheath tumor
Metastases
Metastasis
Neoplasm Metastasis
Nestin
Neurofibrosarcoma - veterinary
Pathology
Peripheral nerves
S100 protein
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Summary:A large abdominal mass was found in a dog. Histopathologically, the surface of the mass was covered with compressed adrenal gland tissue. The neoplastic cells showed typical features of malignant peripheral nerve sheath tumor (MPNST), including Antoni type A and type B pattern, and nuclear palisading. Immunohistochemically, these cells were positive for S100 protein, nerve growth factor receptor, nestin and claudin-1. The dog was euthanized because of the developing multiple metastatic lesions. The metastatic cells showed quite similar histopathological and immunohistochemical features as those in the original tumor. Although MPNST can develop at many body sites, this is the first report of MPNST originating from the adrenal gland in a dog.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.18-0431