Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats

Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of s...

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Published in:Journal of Veterinary Medical Science 2018, Vol.80(10), pp.1553-1557
Main Authors: PARK, Jun Won, NAM, Ki Taek, SHIN, Jae Hoon, KIM, Il Yong, CHOI, Kyung Mi, ROH, Kyung-Jin, OH, Seung Hyun, YUN, Young-Min, SUH, Jun-Gyo, OH, Yang-Seok, YOON, Yeo Sung, SEONG, Je Kyung
Format: Article
Language:English
Subjects:
Animals
Clusterin
Clusterin - biosynthesis
Clusterin - genetics
Hypertension
Immunohistochemistry
Inflammatory diseases
Laboratory Animal Science
Pancreas
Pancreas - metabolism
Pancreas - pathology
Pancreatitis
Pancreatitis - metabolism
Pancreatitis - pathology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Regeneration
Rodents
spontaneous hypertensive rat
tubular complex
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Summary:Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in spontaneously hypertensive rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC). IHC analysis revealed the strong expression of clusterin in dedifferentiated duct-like cells and regenerative islets of TCs. These results imply that clusterin might be involved in the formation of TCs and parenchymal regeneration during rat pancreatitis.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.18-0205