Role of Extracellular Matrix in Development and Cancer Progression

The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is constantly deposited, remodelled, and degraded during development until maturity to maintain tissue homeostasis. The...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-10, Vol.19 (10), p.3028
Main Authors: Walker, Cameron, Mojares, Elijah, Del Río Hernández, Armando
Format: Article
Language:English
Subjects:
Animals
Carcinogenesis - metabolism
Carcinogenesis - pathology
Epithelial-Mesenchymal Transition
Extracellular Matrix - metabolism
Extracellular Matrix - pathology
Humans
Review
Tumor Microenvironment
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Summary:The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is constantly deposited, remodelled, and degraded during development until maturity to maintain tissue homeostasis. The ECM's composition and organization are spatiotemporally regulated to control cell behaviour and differentiation, but dysregulation of ECM dynamics leads to the development of diseases such as cancer. The chemical cues presented by the ECM have been appreciated as key drivers for both development and cancer progression. However, the mechanical forces present due to the ECM have been largely ignored but recently recognized to play critical roles in disease progression and malignant cell behaviour. Here, we review the ways in which biophysical forces of the microenvironment influence biochemical regulation and cell phenotype during key stages of human development and cancer progression.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms19103028