Mixed signals from the cell's antennae: primary cilia in cancer

Primary cilia (PC) are antenna‐like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as Hedgehog and WNT. It is therefore not surprising that a dysfunction of PC is frequently associated with pathologies. Originally, PC were...

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Bibliographic Details
Published in:EMBO reports 2018-11, Vol.19 (11), p.474-n/a
Main Authors: Eguether, Thibaut, Hahne, Michael
Format: Article
Language:English
Subjects:
Antennae
Cancer
Cilia
EMBO03
EMBO37
Hedgehog
Kidney diseases
Life Sciences
Mammalian cells
Organelles
primary cilia
Review
Reviews
Wnt protein
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Summary:Primary cilia (PC) are antenna‐like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as Hedgehog and WNT. It is therefore not surprising that a dysfunction of PC is frequently associated with pathologies. Originally, PC were found to be involved in a variety of diseases commonly referred to as ciliopathies including cystic kidney diseases. Evidence is accumulating that PC play also an important role in cancer formation and regulation, which is the focus of this review. Graphical Abstract Primary cilia are antenna‐like organelles that are essential for the regulation of several essential signaling pathways. This review highlights accumulating evidence that PC are not only involved in specific ciliopathies, but also play important roles in cancer.
ISSN:1469-221X
1469-3178
DOI:10.15252/embr.201846589