EXTH-24. EXPOSURE TO TUMOR TREATING FIELDS INHIBITS DNA REPAIR, INDUCES REPLICATION STRESS AND RENDERS TUMOR CELLS SENSITIVE TO AGENTS THAT IMPINGE UPON THESE PATHWAYS

Abstract Tumor treating fields (TTFields) are low-intensity, intermediate frequency, alternating electric fields applied non-invasively across a tumor. Optune (NovoCure), a TTFields delivery device, has been approved for recurrent and newly diagnosed glioblastoma and clinical trials are ongoing for...

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Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2018-11, Vol.20 (suppl_6), p.vi90-vi90
Main Authors: Story, Michael, Karanam, Narasimha, Ding, Lianghao, Sishc, Brock, Saha, Debabrata
Format: Article
Language:English
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Summary:Abstract Tumor treating fields (TTFields) are low-intensity, intermediate frequency, alternating electric fields applied non-invasively across a tumor. Optune (NovoCure), a TTFields delivery device, has been approved for recurrent and newly diagnosed glioblastoma and clinical trials are ongoing for other cancers. To further understand the molecular mechanisms underlying TTFields sensitivity beyond the anti-mitotic effects already described, we monitored temporal gene expression changes in 5 non-small cell lung cancer (NSCLC) cell lines whose response to TTFields is variable. We found the expression of the BRCA1 DNA damage repair pathway, as well as other DNA repair/checkpoint pathways were significantly downregulated (P
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/noy148.373