Preconception Plasma Phospholipid Fatty Acids and Fecundability

Fatty acids (FAs) are important for reproductive processes, including steroidogenesis, though associations with fecundability, as measured by time to pregnancy (TTP), are unclear. To investigate the relationship between preconception plasma phospholipid FA (PPFA) levels and time to human chorionic g...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2018-12, Vol.103 (12), p.4501-4510
Main Authors: Mumford, Sunni L, Browne, Richard W, Kim, Keewan, Nichols, Christina, Wilcox, Brian, Silver, Robert M, Connell, Matthew T, Holland, Tiffany L, Kuhr, Daniel L, Omosigho, Ukpebo R, Perkins, Neil J, Radin, Rose, Sjaarda, Lindsey A, Schisterman, Enrique F
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Chorionic gonadotropin
Chorionic Gonadotropin - urine
Clinical s
Fatty acids
Fatty Acids, Unsaturated - blood
Fatty Acids, Unsaturated - physiology
Female
Fish oils
Gonadotropins
Humans
Linoleic acid
Phospholipids
Phospholipids - blood
Phospholipids - physiology
Pituitary (anterior)
Polyunsaturated fatty acids
Pregnancy
Prospective Studies
Steroidogenesis
Time-to-Pregnancy - physiology
Young Adult
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Summary:Fatty acids (FAs) are important for reproductive processes, including steroidogenesis, though associations with fecundability, as measured by time to pregnancy (TTP), are unclear. To investigate the relationship between preconception plasma phospholipid FA (PPFA) levels and time to human chorionic gonadotropin-pregnancy among women with prior pregnancy loss. Prospective cohort of 1228 women attempting pregnancy (aged 18 to 40 years, with one or two prior pregnancy losses) followed for up to six cycles at four US university medical centers during 2006 to 2012. PPFA levels were measured at baseline. Associations with fecundability overall and by body mass index (BMI) group after adjusting for confounders were estimated using fecundability odds ratios (FORs) and 95% CIs. False discovery rate (FDR) was used to account for multiple comparisons. Monounsaturated fatty acids (MUFAs) were associated with increased fecundability or shorter TTP [FOR, 1.08 (95% CI, 1.01 to 1.16) per unit increase in percentage of total FAs], whereas polyunsaturated fatty acids (PUFAs) were associated with decreased fecundability or longer TTP [FOR, 0.95 (95% CI, 0.91 to 1.00) per 1% change], though associations only remained significant after FDR adjustment among women with BMI
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2018-00448