Pod-Like Supramicelles with Multicompartment Hydrophobic Cores Prepared by Self-Assembly of Modified Chitosan

In this paper, pod-like supramicelles with multicompartment hydrophobic cores were prepared by selfassembly of amphiphilic N-phthaloylchitosan-g-poly(N-vinylcaprolactam)(PHCS-g-PNVCL) in aqueous medium. The employed biocompatible amphiphilic polymer was synthesized by grafting the carboxyl terminate...

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Bibliographic Details
Published in:Nano-micro letters 2016-04, Vol.8 (2), p.151-156
Main Authors: Wang, Yiming, Wang, Jie, Wang, Tongshuai, Xu, Yisheng, Shi, Lei, Wu, Yongtao, Li, Li, Guo, Xuhong
Format: Article
Language:English
Subjects:
Chitosan
Graft
copolymers
Amphiphiles
Self-assembly
Multicompartment
Engineering
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
supramicelles
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Summary:In this paper, pod-like supramicelles with multicompartment hydrophobic cores were prepared by selfassembly of amphiphilic N-phthaloylchitosan-g-poly(N-vinylcaprolactam)(PHCS-g-PNVCL) in aqueous medium. The employed biocompatible amphiphilic polymer was synthesized by grafting the carboxyl terminated poly(N-vinylcaprolactam)(PNVCL-COOH) chains onto N-phthaloylchitosan(PHCS) backbone.~1H NMR and FTIR results confirmed the molecular structure of the copolymers. The morphology of the supramicelles assembled by PHCS-g-PNVCL was revealed by means of TEM and polarized light microscope. In solution, the supramicelles were very stable as monitored by DLS and zeta potential measurements. Temperature and p H presented significant influences on the size and size distribution of the supramicelles. These supramicelles with multicompartment hydrophobic cores should be ideal biomimetic systems with promising applications in drug delivery.
ISSN:2150-5551
2311-6706
2150-5551
DOI:10.1007/s40820-015-0070-4