Usefulness of glycated albumin in decisions regarding the discontinuation of a diabetes drug and factors associated with poor glycemic control following discontinuation in patients with type 2 diabetes mellitus

• Published in: Diabetology international 2017-03, Vol.8 (1), p.39-44
• Main Authors: Masumoto, Norio, Otsuki, Hiroaki, Iwakawa, Seigo, Inada, Shinya, Koga, Masafumi
• Format: Article
• Language: English
• Subjects: Autoimmune diseases; Diabetes; Diabetes mellitus; Endocrinology; Glucose; Glucose monitoring; Hemoglobin; Immunology; Insulin secretion; Medicine; Medicine & Public Health; Metabolic Diseases; Original; Original Article
• ISSN: 2190-1678; 2190-1686
• DOI: 10.1007/s13340-016-0274-y

We studied the usefulness of glycated albumin (GA) for decisions regarding the discontinuation of a diabetes drug in type 2 diabetic patients with good glycemic control, and the factors associated with increases in GA following discontinuation of a diabetes drug in patients with type 2 diabetes mellitus. Sixteen patients (12 males and 4 females) were enrolled in the present study and discontinued one diabetes drug. When the change in GA was less than 1 % at 4 weeks after the discontinuation of the diabetes drug (ΔGA4w), discontinuation was continued (the continuous group, n  = 10), but when the change in GA was more than a 1 %, the discontinued diabetes drug was resumed (the resume group, n  = 6). In the continuous group, HbA1c at 12 weeks after discontinuation (6.2 ± 0.6 %) remained unchanged from its value at discontinuation (6.2 ± 0.7 %) , but it was significantly elevated at 12 weeks after discontinuation in the resume group (changing from 6.3 ± 0.1 to 7.0 ± 0.6 %). Age, duration of diabetes, and GA were significantly lower while body mass index (BMI) was significantly higher in the continuous group than in the resume group, but no significant difference in HbA1c was observed between the groups. The discontinuation of a diabetes drug in patients with low insulin secretion must be performed carefully because factors such as duration of diabetes, BMI, and GA showed significant differences between the continuous group and resume group in our study, and these indicators are known to be linked with insulin secretion.