Strong association between vertebral endplate defect and Modic change in the general population

Modic change (MC) is considered an independent risk factor for low back pain (LBP) but its aetiology remains unclear. In this cross-sectional, large-scale population-based study we sought to characterise associations between endplate defect (ED) and MC in a population sample of broad age range. The...

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Bibliographic Details
Published in:Scientific reports 2018-11, Vol.8 (1), p.16630-8, Article 16630
Main Authors: Määttä, Juhani H., Rade, Marinko, Freidin, Maxim B., Airaksinen, Olavi, Karppinen, Jaro, Williams, Frances M. K.
Format: Article
Language:English
Subjects:
692/4023/1671/1811
692/499
Defects
Degeneration
Humanities and Social Sciences
Intervertebral discs
Low back pain
multidisciplinary
Pain
Population
Population studies
Risk factors
Science
Science (multidisciplinary)
Vertebrae
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Summary:Modic change (MC) is considered an independent risk factor for low back pain (LBP) but its aetiology remains unclear. In this cross-sectional, large-scale population-based study we sought to characterise associations between endplate defect (ED) and MC in a population sample of broad age range. The study population consisted of 831 twin volunteers (including 4155 discs and 8310 endplates) from TwinsUK. Lumbar T2-weighted MR images were coded for ED and MC. Total endplate (TEP) score was calculated at each intervertebral disc while receiver operating curves (ROC) were calculated to define critical endplate values predictive of MC. MC was detected in 32.1% of the subjects, with a significantly higher prevalence at lower lumbar levels (3.5% at L1/2-L3/4 vs. 15.9% at L4/5-L5/S1, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-34933-3