HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-01, Vol.54 (68), p.9442-9445
Main Authors: Amato, Jussara, Madanayake, Thushara W, Iaccarino, Nunzia, Novellino, Ettore, Randazzo, Antonio, Hurley, Laurence H, Pagano, Bruno
Format: Article
Language:English
Subjects:
Biological activity
Cell Line, Tumor
Fluorescein - chemistry
Fluorescent Dyes - chemistry
G-Quadruplexes
Gene expression
Gene Expression Regulation
HMGB1 Protein - genetics
HMGB1 Protein - metabolism
Humans
Promoter Regions, Genetic
Protein Binding
Proteins
Proto-Oncogene Proteins p21(ras) - genetics
Proto-Oncogene Proteins p21(ras) - metabolism
RNA, Small Interfering - genetics
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Summary:This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc03614d