Phase Contrast Magnetic Resonance Imaging in the Rat Common Carotid Artery

Phase contrast magnetic resonance imaging (PC-MRI) is a noninvasive approach that can quantify flow-related parameters such as blood flow. Previous studies have shown that abnormal blood flow may be associated with systemic vascular risk. Thus, PC-MRI can facilitate the translation of data obtained...

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Bibliographic Details
Published in:Journal of visualized experiments 2018-09 (139)
Main Authors: Chiu, Shao-Chieh, Hsu, Shih-Ting, Huang, Chiun-Wei, Shen, Wu-Chung, Peng, Shin-Lei
Format: Article
Language:English
Subjects:
Animals
Blood Flow Velocity
Carotid Artery, Common - diagnostic imaging
Carotid Artery, Common - physiology
Magnetic Resonance Imaging, Cine - methods
Male
Rats
Reproducibility of Results
Retraction
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Summary:Phase contrast magnetic resonance imaging (PC-MRI) is a noninvasive approach that can quantify flow-related parameters such as blood flow. Previous studies have shown that abnormal blood flow may be associated with systemic vascular risk. Thus, PC-MRI can facilitate the translation of data obtained from animal models of cardiovascular diseases to pertinent clinical investigations. In this report, we describe the procedure for measuring blood flow in the common carotid artery (CCA) of rats using cine-gated PC-MRI and discuss relevant analysis methods. This procedure can be performed in a live, anesthetized animal and does not require euthanasia after the procedure. The proposed scanning parameters yield repeatable measurements for blood flow, indicating excellent reproducibility of the results. The PC-MRI procedure described in this article can be used for pharmacological testing, pathophysiological assessment, and cerebral hemodynamics evaluation.
ISSN:1940-087X
1940-087X
DOI:10.3791/57304