Transcranial Direct Current Stimulation (tDCS) in Mice

Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique proposed as an alternative or complementary treatment for several neuropsychiatric diseases. The biological effects of tDCS are not fully understood, which is in part explained due to the difficulty in obtaini...

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Bibliographic Details
Published in:Journal of visualized experiments 2018-09 (139)
Main Authors: de Souza Nicolau, Eduardo, de Alvarenga, Kevin Augusto Farias, Tenza-Ferrer, Helia, Nogueira, Matheus Carvalho Alves, Rezende, Fernanda Donizete, Nicolau, Nycolle Ferreira, Collodetti, Mélcar, de Miranda, Débora Marques, Magno, Luiz Alexandre Viana, Romano-Silva, Marco Aurélio
Format: Article
Language:English
Subjects:
Animals
Brain - physiology
Electrodes, Implanted
Humans
Mice
Neuroscience
Transcranial Direct Current Stimulation - methods
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Summary:Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique proposed as an alternative or complementary treatment for several neuropsychiatric diseases. The biological effects of tDCS are not fully understood, which is in part explained due to the difficulty in obtaining human brain tissue. This protocol describes a tDCS mouse model that uses a chronically implanted electrode allowing the study of the long-lasting biological effects of tDCS. In this experimental model, tDCS changes the cortical gene expression and offers a prominent contribution to the understanding of the rationale for its therapeutic use.
ISSN:1940-087X
1940-087X
DOI:10.3791/58517