Circulating inflammatory markers and colorectal cancer risk: A prospective case‐cohort study in Japan

Blood levels of inflammation‐related markers may reveal molecular pathways contributing to carcinogenesis. To date, prospective associations with colorectal cancer (CRC) risk have been based on few studies with limited sets of analytes. We conducted a case‐cohort study within the Japan Public Health...

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Bibliographic Details
Published in:International journal of cancer 2018-12, Vol.143 (11), p.2767-2776
Main Authors: Song, Minkyo, Sasazuki, Shizuka, Camargo, M. Constanza, Shimazu, Taichi, Charvat, Hadrien, Yamaji, Taiki, Sawada, Norie, Kemp, Troy J., Pfeiffer, Ruth M., Hildesheim, Allan, Pinto, Ligia A., Rabkin, Charles S., Tsugane, Shoichiro
Format: Article
Language:English
Subjects:
biomarker
Blood levels
Cancer
Cancer screening
Carcinogenesis
CCL3 protein
Chemokines
Cohort analysis
Colorectal cancer
Colorectal carcinoma
Health risk assessment
Health risks
Inflammation
Ligands
Medical research
Medical screening
Monocyte chemoattractant protein 1
Plasma levels
Proteins
Public health
Rectum
Statistical models
Statistics
Tumor necrosis factor receptor 2
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Summary:Blood levels of inflammation‐related markers may reveal molecular pathways contributing to carcinogenesis. To date, prospective associations with colorectal cancer (CRC) risk have been based on few studies with limited sets of analytes. We conducted a case‐cohort study within the Japan Public Health Center‐based Prospective Study Cohort II, comparing 457 incident CRC cases during median 18 years follow‐up with a random subcohort of 774 individuals. Baseline plasma levels of 62 cytokines, soluble receptors, acute‐phase proteins, and growth factor markers were measured using Luminex bead‐based assays. We estimated hazard ratios (HRs) associating each marker with CRC risk by Cox proportional hazards models adjusted for potential confounders. Subanalyses compared cases by years after blood draw (
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.31821