Comprehensive network map of interferon gamma signaling

• Published in: Journal of cell communication and signaling 2018-12, Vol.12 (4), p.745-751
• Main Authors: Bhat, Mohd Younis, Solanki, Hitendra S., Advani, Jayshree, Khan, Aafaque Ahmad, Keshava Prasad, T. S., Gowda, Harsha, Thiyagarajan, Saravanan, Chatterjee, Aditi
• Format: Article
• Language: English
• Subjects: Adaptive immunity; Apoptosis; Biomedical and Life Sciences; Biomedicine; Cancer; Cell Biology; Cytokines; Immune response (cell-mediated); Immunomodulation; Immunosurveillance; Interferon; Interferon gamma receptor; Interferon response factors; Interferon‐gamma activated sequence and PathVisio; Kinases; Life Sciences; Mammalian cells; Nuts and Bolts; Post-translation; Protein interaction; Signal transducer and activator of transcription; Signal transduction; Tumor cells; γ-Interferon
• ISSN: 1873-9601; 1873-961X
• DOI: 10.1007/s12079-018-0486-y

Interferon gamma (IFN-γ), is a cytokine, which is an important regulator of host defense system by mediating both innate and adaptive immune responses. IFN-γ signaling is primarily associated with inflammation and cell-mediated immune responses. IFN-γ is also represented as antitumor cytokine which facilitates immunosurveillance in tumor cells. In addition, IFN-γ mediated signaling also elicits pro-tumorigenic transformations and promotes tumor progression. Impact of IFN-γ signaling in mammalian cells has been widely studied which indicate that IFN-γ orchestrates distinct cellular functions including immunomodulation, leukocyte trafficking, apoptosis, anti-microbial, and both anti- and pro-tumorigenic role. However, a detailed network of IFN-γ signaling pathway is currently lacking. Therefore, we systematically curated the literature information pertaining to IFN-γ signaling and develop a comprehensive signaling network to facilitate better understanding of IFN-γ mediated signaling. A total of 124 proteins were catalogued that were experimentally proven to be involved in IFN-γ signaling cascade. These 124 proteins were found to participate in 81 protein-protein interactions, 94 post-translational modifications, 20 translocation events, 54 activation/inhibiton reactions. Further, 236 differential expressed genes were also documented in IFN-γ mediated signaling. IFN-γ signaling pathway is made freely available to scientific audience through NetPath at ( http://www.netpath.org/pathways?path_id=NetPath_32 ). We believe that documentation of reactions pertaining to IFN-γ signaling and development of pathway map will facilitate further research in IFN-γ associated human diseases including cancer.