Shape oscillations of single blood drops: applications to human blood and sickle cell disease

Sickle cell disease (SCD) is an inherited blood disorder associated with severe anemia, vessel occlusion, poor oxygen transport and organ failure. The presence of stiff and often sickle-shaped red blood cells is the hallmark of SCD and is believed to contribute to impaired blood rheology and organ d...

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Bibliographic Details
Published in:Scientific reports 2018-11, Vol.8 (1), p.16794-8, Article 16794
Main Authors: Hosseinzadeh, Vahideh Ansari, Brugnara, Carlo, Holt, R. Glynn
Format: Article
Language:English
Subjects:
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639/166/985
Blood
Erythrocytes
Fetuses
Hematological diseases
Hemoglobin
Humanities and Social Sciences
Hydroxyurea
Measurement techniques
multidisciplinary
Occlusion
Oscillations
Physical properties
Rheology
Science
Science (multidisciplinary)
Sickle cell disease
Viscosity
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Summary:Sickle cell disease (SCD) is an inherited blood disorder associated with severe anemia, vessel occlusion, poor oxygen transport and organ failure. The presence of stiff and often sickle-shaped red blood cells is the hallmark of SCD and is believed to contribute to impaired blood rheology and organ damage. Most existing measurement techniques of blood and red blood cell physical properties require sample contact and/or large sample volume, which is problematic for pediatric patients. Acoustic levitation allows rheological measurements in a single drop of blood, simultaneously eliminating the need for both contact containment and manipulation of samples. The technique shows that the shape oscillation of blood drops is able to assess blood viscosity in normal and SCD blood and demonstrates an abnormally increased viscosity in SCD when compared with normal controls. Furthermore, the technique is sensitive enough to detect viscosity changes induced by hydroxyurea treatment, and their dependence on the total fetal hemoglobin content of the sample. Thus this technique may hold promise as a monitoring tool for assessing changes in blood rheology in sickle cell and other hematological diseases.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-34600-7