Cerebral Motor Functional Connectivity at the Acute Stage: An Outcome Predictor of Ischemic Stroke

Sixty-seven patients with first acute ischemic stroke onset between 3 to 7 days and 25 age- and sex- matched controls were analyzed for the performance of a resting-state functional MRI to investigate whether the functional connectivity (FC) of the motor network in acute ischemic stroke is independe...

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Bibliographic Details
Published in:Scientific reports 2018-11, Vol.8 (1), p.16803-11, Article 16803
Main Authors: Chi, Nai-Fang, Ku, Hsiao-Lun, Chen, David Yen-Ting, Tseng, Ying-Chi, Chen, Chi-Jen, Lin, Ying-Chin, Hsieh, Yi-Chen, Chan, Lung, Chiou, Hung-Yi, Hsu, Chung Y., Hu, Chaur-Jong
Format: Article
Language:English
Subjects:
59/36
631/1647/245/1627
692/617/375/1370/534
Adult
Aged
Brain Ischemia - diagnosis
Brain Ischemia - diagnostic imaging
Brain Ischemia - physiopathology
Brain Mapping
Case-Control Studies
Cerebral hemispheres
Cortex (motor)
Functional magnetic resonance imaging
Humanities and Social Sciences
Humans
Ischemia
Magnetic Resonance Imaging
Male
Middle Aged
Motor Cortex - physiopathology
multidisciplinary
Multivariate analysis
Nerve Net - physiopathology
Neural Pathways - physiopathology
Prognosis
Science
Science (multidisciplinary)
Stroke
Stroke - diagnosis
Stroke - diagnostic imaging
Stroke - physiopathology
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Summary:Sixty-seven patients with first acute ischemic stroke onset between 3 to 7 days and 25 age- and sex- matched controls were analyzed for the performance of a resting-state functional MRI to investigate whether the functional connectivity (FC) of the motor network in acute ischemic stroke is independently associated with functional outcomes. The FC of cortical motor network and default mode network was analyzed. The FC was compared between controls, patients with favorable outcomes (modified Rankin Scale, mRS ≤1), and patients with unfavorable outcomes (mRS ≥2) at 3 months. Of the 67 patients, 23 (34%) exhibited unfavorable outcomes. In multivariate analysis, the FC between ipsilesional primary motor cortex (M1) and contralesional dorsal premotor area (PMd) ≤0.63, were independently associated with unfavorable outcomes (odds ratio = 6.32, P  = 0.032), whereas the FC of default mode network was not different between groups. The interhemispheric FC of the motor network is an independent predictor of functional outcomes in patients with acute ischemic stroke.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-35192-y