Stress, inflammation, and eicosanoids: an emerging perspective

Clinical and experimental studies support the notion that adrenergic stimulation and chronic stress affect inflammation, metabolism, and tumor growth. Eicosanoids are also known to heavily influence inflammation while regulating certain stress responses. However, additional work is needed to underst...

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Bibliographic Details
Published in:Cancer and metastasis reviews 2018-09, Vol.37 (2-3), p.203-211
Main Authors: Umamaheswaran, Sujanitha, Dasari, Santosh K., Yang, Peiying, Lutgendorf, Susan K., Sood, Anil K.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Care and treatment
Development and progression
Disease Susceptibility
Eicosanoids
Eicosanoids - metabolism
Humans
Inflammation
Inflammation - complications
Inflammation - etiology
Inflammation - metabolism
Lipid Metabolism
Metabolic Networks and Pathways
Metabolic pathways
Metabolism
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Occupational health
Oncology
Stress
Stress, Physiological
Stress, Psychological - complications
Stress, Psychological - metabolism
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Summary:Clinical and experimental studies support the notion that adrenergic stimulation and chronic stress affect inflammation, metabolism, and tumor growth. Eicosanoids are also known to heavily influence inflammation while regulating certain stress responses. However, additional work is needed to understand the full extent of interactions between the stress-related pathways and eicosanoids. Here, we review the potential influences that stress, inflammation, and metabolic pathways have on each other, in the context of eicosanoids. Understanding the intricacies of such interactions could provide insights on how systemic metabolic effects mediated by the stress pathways can be translated into therapies for cancer and other diseases.
ISSN:0167-7659
1573-7233
DOI:10.1007/s10555-018-9741-1