Fat fibrosis: friend or foe?

At the simplest level, obesity is the manifestation of an imbalance between caloric intake and expenditure; however, the pathophysiological mechanisms that govern the development of obesity and associated complications are enormously complex. Fibrosis within the adipose tissue compartment is one suc...

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Bibliographic Details
Published in:JCI insight 2018-10, Vol.3 (19)
Main Authors: Datta, Ritwik, Podolsky, Michael J, Atabai, Kamran
Format: Article
Language:English
Subjects:
Adipocytes - drug effects
Adipocytes - immunology
Adipocytes - metabolism
Adipose Tissue - cytology
Adipose Tissue - immunology
Adipose Tissue - pathology
Animals
Anti-Obesity Agents - pharmacology
Anti-Obesity Agents - therapeutic use
Disease Models, Animal
Extracellular Matrix - drug effects
Extracellular Matrix - immunology
Extracellular Matrix - metabolism
Fibrosis
Humans
Inflammation Mediators - antagonists & inhibitors
Inflammation Mediators - immunology
Inflammation Mediators - metabolism
Obesity - drug therapy
Obesity - etiology
Obesity - pathology
Review
Stromal Cells - drug effects
Stromal Cells - immunology
Stromal Cells - metabolism
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Summary:At the simplest level, obesity is the manifestation of an imbalance between caloric intake and expenditure; however, the pathophysiological mechanisms that govern the development of obesity and associated complications are enormously complex. Fibrosis within the adipose tissue compartment is one such factor that may influence the development of obesity and/or obesity-related comorbidities. Furthermore, the functional consequences of adipose tissue fibrosis are a matter of considerable debate, with evidence that fibrosis serves both adaptive and maladaptive roles. Tissue fibrosis itself is incompletely understood, and multiple cellular and molecular pathways are involved in the development, maintenance, and resolution of the fibrotic state. Within the context of obesity, fibrosis influences molecular and cellular events that relate to adipocytes, inflammatory cells, inflammatory mediators, and supporting adipose stromal tissue. In this Review, we explore what is known about the interplay between the development of adipose tissue fibrosis and obesity, with a view toward future investigative and therapeutic avenues.
ISSN:2379-3708
2379-3708
DOI:10.1172/jci.insight.122289