Hybrid in vitro diffusion cell for simultaneous evaluation of hair and skin decontamination: temporal distribution of chemical contaminants

Most casualty or personnel decontamination studies have focused on removing contaminants from the skin. However, scalp hair and underlying skin are the most likely areas of contamination following airborne exposure to chemicals. The aim of this study was to investigate the interactions of contaminan...

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Published in:Scientific reports 2018-11, Vol.8 (1), p.16906-9, Article 16906
Main Authors: Matar, Hazem, Amer, Nevine, Kansagra, Sneha, Pinhal, Andreia, Thomas, Elliot, Townend, Scott, Larner, Joanne, Chilcott, Robert P.
Format: Article
Language:English
Subjects:
13
692/700/459/1748
692/700/478/2772
Air pollution
Chemical contaminants
Chemical pollution
Contaminants
Contamination
Decontamination
Diffusion
Hair
Humanities and Social Sciences
multidisciplinary
Scalp
Science
Science (multidisciplinary)
Skin
Skin tests
Temporal distribution
Test systems
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cited_by cdi_FETCH-LOGICAL-c513t-ebafef9c93cb4b89e96ec7954a2bfb89a11f8f232aea9f789960987d6119336c3
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container_title Scientific reports
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creator Matar, Hazem
Amer, Nevine
Kansagra, Sneha
Pinhal, Andreia
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Townend, Scott
Larner, Joanne
Chilcott, Robert P.
description Most casualty or personnel decontamination studies have focused on removing contaminants from the skin. However, scalp hair and underlying skin are the most likely areas of contamination following airborne exposure to chemicals. The aim of this study was to investigate the interactions of contaminants with scalp hair and underlying skin using a hybrid in vitro diffusion cell model. The in vitro hybrid test system comprised “curtains” of human hair mounted onto sections of excised porcine skin within a modified diffusion cell. The results demonstrated that hair substantially reduced underlying scalp skin contamination and that hair may provide a limited decontamination effect by removing contaminants from the skin surface. This hybrid test system may have application in the development of improved chemical incident response processes through the evaluation of various hair and skin decontamination strategies.
doi_str_mv 10.1038/s41598-018-35105-z
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subjects 13
692/700/459/1748
692/700/478/2772
Air pollution
Chemical contaminants
Chemical pollution
Contaminants
Contamination
Decontamination
Diffusion
Hair
Humanities and Social Sciences
multidisciplinary
Scalp
Science
Science (multidisciplinary)
Skin
Skin tests
Temporal distribution
Test systems
title Hybrid in vitro diffusion cell for simultaneous evaluation of hair and skin decontamination: temporal distribution of chemical contaminants
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