The prognostic value of C-reactive protein/albumin ratio in nasopharyngeal carcinoma: a meta-analysis

The C-reactive protein/albumin ratio (CRP/Alb ratio) has been reported to have promising prognostic value in several cancers. The current meta-analysis was conducted to better define the prognostic value of CRP/Alb ratio in patients with nasopharyngeal carcinoma (NPC). The Web of Science, Embase, Co...

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Bibliographic Details
Published in:Bioscience reports 2018-12, Vol.38 (6)
Main Authors: Gao, Nan, Yang, Ruo-Nan, Meng, Zhen, Wang, Wan-Hai
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - blood
C-Reactive Protein - metabolism
Disease-Free Survival
Female
Humans
Male
Nasopharyngeal Carcinoma - blood
Nasopharyngeal Carcinoma - pathology
Neoplasm Metastasis
Prognosis
Serum Albumin - metabolism
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Summary:The C-reactive protein/albumin ratio (CRP/Alb ratio) has been reported to have promising prognostic value in several cancers. The current meta-analysis was conducted to better define the prognostic value of CRP/Alb ratio in patients with nasopharyngeal carcinoma (NPC). The Web of Science, Embase, Cochrane Library databases, and PubMed were searched up to 25 February 2018 for the information on CRP/Alb ratio and outcomes of NPC. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (95% CIs) were used to evaluate the association between CRP/Alb ratio and survival outcomes in NPC. A total of five studies with 5533 patients with NPC were included. Pooled results showed that high CRP/Alb ratio was associated with poor overall survival (OS) (HR = 1.51, 95% CI: 1.30-1.75,
ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20180686