Aptamer-based targeted therapy

Precision medicine holds great promise to harness genetic and epigenetic cues for targeted treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative diseases, to cardiovascular diseases. The proteomic profiles resulting from the unique genetic and epigenetic signature...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2018-09, Vol.134, p.65-78
Main Authors: Zhu, Guizhi, Chen, Xiaoyuan
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Aptamer
Aptamer-drug conjugate
Aptamers, Nucleotide - chemistry
Aptamers, Nucleotide - therapeutic use
Cardiovascular Diseases - drug therapy
Drug delivery
Drug Delivery Systems
Humans
Neoplasms - drug therapy
Neurodegenerative Diseases - drug therapy
Neuroprotective Agents - chemistry
Neuroprotective Agents - therapeutic use
Nucleic acid therapeutics
Precision Medicine
Targeted immunotherapy
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Summary:Precision medicine holds great promise to harness genetic and epigenetic cues for targeted treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative diseases, to cardiovascular diseases. The proteomic profiles resulting from the unique genetic and epigenetic signatures represent a class of relatively well accessible molecular targets for both interrogation (e.g., diagnosis, prognosis) and intervention (e.g., targeted therapy) of these diseases. Aptamers are promising for such applications by specific binding with cognate disease biomarkers. Nucleic acid aptamers are a class of DNA or RNA with unique three-dimensional conformations that allow them to specifically bind with target molecules. Aptamers can be relatively easily screened, reproducibly manufactured, programmably designed, and chemically modified for various biomedical applications, including targeted therapy. Aptamers can be chemically modified to resist enzymatic degradation or optimize their pharmacological behaviors, which ensured their chemical integrity and bioavailability under physiological conditions. In this review, we will focus on recent progress and discuss the challenges and opportunities in the research areas of aptamer-based targeted therapy in the forms of aptamer therapeutics and aptamer-drug conjugates (ApDCs). [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2018.08.005