EFFICACY OF PROPOLIS ON DENTURE STOMATITIS IN OLDER ADULTS: A MULTICENTRIC RANDOMIZED TRIAL

Our hypothesis tested the efficacy and safety of standard formulation of Brazilian propolis extract gel compared to miconazole oral gel for the treatment of denture stomatitis due Candida spp infection in older adults. A total of 40 older patients were randomly allocated in a non-inferiority clinica...

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Published in:Innovation in aging 2017-06, Vol.1 (Suppl 1), p.398-398
Main Authors: Pina, G., Lia, E.N., Berreta, A.A., Nascimento, A.P., Torres, E.C., Buszinski, A.M., Coelho, E.B., Martins, V.d.
Format: Article
Language:English
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Summary:Our hypothesis tested the efficacy and safety of standard formulation of Brazilian propolis extract gel compared to miconazole oral gel for the treatment of denture stomatitis due Candida spp infection in older adults. A total of 40 older patients were randomly allocated in a non-inferiority clinical trial (NCT02818803) into two groups. The control group (MIC) received 20 mg/g miconazole oral gel and the study group (PROP) received mucoadhesive formulation containing standardized extract of 2% propolis (EPP-AF®) during 14 days. Patients were examined by a dentist on days 1, 7 and 14. The Newton’s score was used to assess the denture stomatitis. The colony forming unity count (CFU/mL) was quantified and compared before and after the treatment (days 1 and 14). Age, gender, duration of complete denture’s use, baseline Newton’s score, and baseline CFU/mL did not differ between groups. Both treatments reduced the Newton’s score (P
ISSN:2399-5300
DOI:10.1093/geroni/igx004.1439