Studies with beta-oxoalkanonitriles: simple novel synthesis of 3-[2,6-diaryl-4- pyridyl]-3-oxopropanenitriles

Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4-arylbutanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b. Treatment of the latter with acetonitrile afforded novel beta-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2008-12, Vol.13 (12), p.3140-3148
Main Authors: Riyadh, Sayed M, Al-Matar, Hamad M, Elnagdi, Mohamed H
Format: Article
Language:English
Subjects:
Nitriles - chemical synthesis
Nitriles - chemistry
Nitrogen - chemistry
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Summary:Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4-arylbutanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b. Treatment of the latter with acetonitrile afforded novel beta-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave the corresponding pyridyl aminopyrazoles 8a,b and pyridyl aminoisoxazoles 10a,b, respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules13123140