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Vanadium complex: an appropriate candidate for killing hepatocellular carcinoma cancerous cells
Hepatocellular carcinoma (HCC) is a prevalent human malignancy which its drug resistance is increasing world-wide. This project was designed to assess the anti-cancer effects of 4-bromo-2-(((5-chloro-2-hydroxyphenyl) imino) methyl) phenol ([IV(L)] complex) on the HepG2 cell line and also L929 cells,...
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| Published in: | Biometals 2018-12, Vol.31 (6), p.981-990 |
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| container_end_page | 990 |
| container_issue | 6 |
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| container_title | Biometals |
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| creator | Bakhshi Aliabad, Hamid Khanamani Falahati-pour, Soudeh Ahmadirad, Hadis Mohamadi, Maryam Hajizadeh, Mohammad Reza Mahmoodi, Mehdi |
| description | Hepatocellular carcinoma (HCC) is a prevalent human malignancy which its drug resistance is increasing world-wide. This project was designed to assess the anti-cancer effects of 4-bromo-2-(((5-chloro-2-hydroxyphenyl) imino) methyl) phenol ([IV(L)] complex) on the HepG2 cell line and also L929 cells, as normal cells. HepG2 and L929 cells were cultured in RPMI culture medium and the survival rates of the cells were determined after 24 and 48 h using MTT assay to find IC50 concentration of vanadium m, [IV(L)] complex. The early apoptosis and necrosis/late apoptosis were determined by means of annexin V/PI apoptosis detection kit. The results revealed that vanadium m, [IV(L)] complex induce early apoptosis higher in HepG2 cell line than L929 cells. The rates of necrosis/late apoptosis were also induced in HepG2 cells more than L929 cells. Based on the results, vanadium m, [IV(L)] complex might be considered as a safe new drug for treatment of HCC with low side effects on control liver cells. |
| doi_str_mv | 10.1007/s10534-018-0139-x |
| format | article |
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This project was designed to assess the anti-cancer effects of 4-bromo-2-(((5-chloro-2-hydroxyphenyl) imino) methyl) phenol ([IV(L)] complex) on the HepG2 cell line and also L929 cells, as normal cells. HepG2 and L929 cells were cultured in RPMI culture medium and the survival rates of the cells were determined after 24 and 48 h using MTT assay to find IC50 concentration of vanadium m, [IV(L)] complex. The early apoptosis and necrosis/late apoptosis were determined by means of annexin V/PI apoptosis detection kit. The results revealed that vanadium m, [IV(L)] complex induce early apoptosis higher in HepG2 cell line than L929 cells. The rates of necrosis/late apoptosis were also induced in HepG2 cells more than L929 cells. Based on the results, vanadium m, [IV(L)] complex might be considered as a safe new drug for treatment of HCC with low side effects on control liver cells.</description><identifier>ISSN: 0966-0844</identifier><identifier>EISSN: 1572-8773</identifier><identifier>DOI: 10.1007/s10534-018-0139-x</identifier><identifier>PMID: 30255365</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animals ; Annexin V ; Anticancer properties ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - pathology ; Cell Biology ; Cell culture ; Cell Death - drug effects ; Cell Proliferation - drug effects ; Dose-Response Relationship, Drug ; Drug resistance ; Drug Screening Assays, Antitumor ; Gangrene ; Hep G2 Cells ; Hepatocellular carcinoma ; Hepatocytes ; Humans ; Life Sciences ; Liver ; Liver cancer ; Liver Neoplasms - drug therapy ; Liver Neoplasms - pathology ; Malignancy ; Medicine/Public Health ; Mice ; Microbiology ; Necrosis ; Organometallic Compounds - chemical synthesis ; Organometallic Compounds - chemistry ; Organometallic Compounds - pharmacology ; Pharmacology/Toxicology ; Phenols ; Plant Physiology ; Side effects ; Structure-Activity Relationship ; Survival ; Vanadium ; Vanadium - chemistry ; Vanadium - pharmacology</subject><ispartof>Biometals, 2018-12, Vol.31 (6), p.981-990</ispartof><rights>The Author(s) 2018</rights><rights>BioMetals is a copyright of Springer, (2018). All Rights Reserved. © 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-3c731f05e2b9cc1f422d97f5bf6bf2a65b87d133741fdbea404b8e4701eedf573</citedby><cites>FETCH-LOGICAL-c470t-3c731f05e2b9cc1f422d97f5bf6bf2a65b87d133741fdbea404b8e4701eedf573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30255365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakhshi Aliabad, Hamid</creatorcontrib><creatorcontrib>Khanamani Falahati-pour, Soudeh</creatorcontrib><creatorcontrib>Ahmadirad, Hadis</creatorcontrib><creatorcontrib>Mohamadi, Maryam</creatorcontrib><creatorcontrib>Hajizadeh, Mohammad Reza</creatorcontrib><creatorcontrib>Mahmoodi, Mehdi</creatorcontrib><title>Vanadium complex: an appropriate candidate for killing hepatocellular carcinoma cancerous cells</title><title>Biometals</title><addtitle>Biometals</addtitle><addtitle>Biometals</addtitle><description>Hepatocellular carcinoma (HCC) is a prevalent human malignancy which its drug resistance is increasing world-wide. This project was designed to assess the anti-cancer effects of 4-bromo-2-(((5-chloro-2-hydroxyphenyl) imino) methyl) phenol ([IV(L)] complex) on the HepG2 cell line and also L929 cells, as normal cells. HepG2 and L929 cells were cultured in RPMI culture medium and the survival rates of the cells were determined after 24 and 48 h using MTT assay to find IC50 concentration of vanadium m, [IV(L)] complex. The early apoptosis and necrosis/late apoptosis were determined by means of annexin V/PI apoptosis detection kit. The results revealed that vanadium m, [IV(L)] complex induce early apoptosis higher in HepG2 cell line than L929 cells. The rates of necrosis/late apoptosis were also induced in HepG2 cells more than L929 cells. Based on the results, vanadium m, [IV(L)] complex might be considered as a safe new drug for treatment of HCC with low side effects on control liver cells.</description><subject>Animals</subject><subject>Annexin V</subject><subject>Anticancer properties</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Biology</subject><subject>Cell culture</subject><subject>Cell Death - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug resistance</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Gangrene</subject><subject>Hep G2 Cells</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatocytes</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - pathology</subject><subject>Malignancy</subject><subject>Medicine/Public Health</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Necrosis</subject><subject>Organometallic Compounds - chemical synthesis</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Pharmacology/Toxicology</subject><subject>Phenols</subject><subject>Plant Physiology</subject><subject>Side effects</subject><subject>Structure-Activity Relationship</subject><subject>Survival</subject><subject>Vanadium</subject><subject>Vanadium - chemistry</subject><subject>Vanadium - pharmacology</subject><issn>0966-0844</issn><issn>1572-8773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kU2L1TAYhYM4ONfRH-BGCm7c1Mmbj6Z1IcjgFwy4UbchTd_cydgmNWnl-u8n5Y6jDrgICZznPcnJIeQZ0FdAqTrPQCUXNYW2LN7VhwdkB1KxulWKPyQ72jVNTVshTsnjnK8ppZ2izSNyyimTkjdyR_Q3E8zg16mycZpHPLyuTKjMPKc4J28WrKwJgx-2k4up-u7H0Yd9dYWzWaLFcVxHkwqUrA9xMhtuMcU1V5uYn5ATZ8aMT2_3M_L1_bsvFx_ry88fPl28vaytUHSpuVUcHJXI-s5acIKxoVNO9q7pHTON7Fs1AOdKgBt6NIKKvsUyCoiDk4qfkTdH33ntJxwshiWZUZcMk0m_dDRe_6sEf6X38adumJDln4rBy1uDFH-smBc9-bxFMAFLGs0AWAO87aCgL-6h13FNocTbKOhkKwUtFBwpm2LOCd3dY4DqrT59rE-X-vRWnz6Umed_p7ib-N1XAdgRyEUKe0x_rv6_6w1sQ6h_</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Bakhshi Aliabad, Hamid</creator><creator>Khanamani Falahati-pour, Soudeh</creator><creator>Ahmadirad, Hadis</creator><creator>Mohamadi, Maryam</creator><creator>Hajizadeh, Mohammad Reza</creator><creator>Mahmoodi, Mehdi</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U5</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>K9.</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181201</creationdate><title>Vanadium complex: an appropriate candidate for killing hepatocellular carcinoma cancerous cells</title><author>Bakhshi Aliabad, Hamid ; Khanamani Falahati-pour, Soudeh ; Ahmadirad, Hadis ; Mohamadi, Maryam ; Hajizadeh, Mohammad Reza ; Mahmoodi, Mehdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-3c731f05e2b9cc1f422d97f5bf6bf2a65b87d133741fdbea404b8e4701eedf573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Annexin V</topic><topic>Anticancer properties</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Biology</topic><topic>Cell culture</topic><topic>Cell Death - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug resistance</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Gangrene</topic><topic>Hep G2 Cells</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatocytes</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - pathology</topic><topic>Malignancy</topic><topic>Medicine/Public Health</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Necrosis</topic><topic>Organometallic Compounds - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biometals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakhshi Aliabad, Hamid</au><au>Khanamani Falahati-pour, Soudeh</au><au>Ahmadirad, Hadis</au><au>Mohamadi, Maryam</au><au>Hajizadeh, Mohammad Reza</au><au>Mahmoodi, Mehdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vanadium complex: an appropriate candidate for killing hepatocellular carcinoma cancerous cells</atitle><jtitle>Biometals</jtitle><stitle>Biometals</stitle><addtitle>Biometals</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>31</volume><issue>6</issue><spage>981</spage><epage>990</epage><pages>981-990</pages><issn>0966-0844</issn><eissn>1572-8773</eissn><abstract>Hepatocellular carcinoma (HCC) is a prevalent human malignancy which its drug resistance is increasing world-wide. This project was designed to assess the anti-cancer effects of 4-bromo-2-(((5-chloro-2-hydroxyphenyl) imino) methyl) phenol ([IV(L)] complex) on the HepG2 cell line and also L929 cells, as normal cells. HepG2 and L929 cells were cultured in RPMI culture medium and the survival rates of the cells were determined after 24 and 48 h using MTT assay to find IC50 concentration of vanadium m, [IV(L)] complex. The early apoptosis and necrosis/late apoptosis were determined by means of annexin V/PI apoptosis detection kit. The results revealed that vanadium m, [IV(L)] complex induce early apoptosis higher in HepG2 cell line than L929 cells. The rates of necrosis/late apoptosis were also induced in HepG2 cells more than L929 cells. Based on the results, vanadium m, [IV(L)] complex might be considered as a safe new drug for treatment of HCC with low side effects on control liver cells.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>30255365</pmid><doi>10.1007/s10534-018-0139-x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biometals, 2018-12, Vol.31 (6), p.981-990 |
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| subjects | Animals Annexin V Anticancer properties Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Biochemistry Biomedical and Life Sciences Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Cell Biology Cell culture Cell Death - drug effects Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug resistance Drug Screening Assays, Antitumor Gangrene Hep G2 Cells Hepatocellular carcinoma Hepatocytes Humans Life Sciences Liver Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - pathology Malignancy Medicine/Public Health Mice Microbiology Necrosis Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Pharmacology/Toxicology Phenols Plant Physiology Side effects Structure-Activity Relationship Survival Vanadium Vanadium - chemistry Vanadium - pharmacology |
| title | Vanadium complex: an appropriate candidate for killing hepatocellular carcinoma cancerous cells |
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