Statin intensity and postoperative mortality following open repair of intact abdominal aortic aneurysm

Background There is a lack of evidence for the association between intensive statin therapy and outcomes following vascular surgery. The aim of this study was to evaluate the association between perioperative statin intensity and in‐hospital mortality following open abdominal aortic aneurysm (AAA) r...

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Bibliographic Details
Published in:BJS open 2018-12, Vol.2 (6), p.411-418
Main Authors: Alshaikh, H. N., Bohsali, F., Gani, F., Nejim, B., Malas, M.
Format: Article
Language:English
Subjects:
Aneurysms
Aortic aneurysms
Cardiology
Cardiovascular disease
Codes
Drug dosages
Hospitals
Morbidity
Mortality
Original
Patients
Statins
Studies
Vascular surgery
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Summary:Background There is a lack of evidence for the association between intensive statin therapy and outcomes following vascular surgery. The aim of this study was to evaluate the association between perioperative statin intensity and in‐hospital mortality following open abdominal aortic aneurysm (AAA) repair. Methods Patients undergoing open AAA repair between 2009 and 2015 were identified from the Premier Healthcare Database. Statin use was classified into low, moderate and high intensity, based on American College of Cardiology/American Heart Association guidelines. Supratherapeutic intensity was defined as doses higher than the recommended guidelines. Multivariable logistic regression analyses were undertaken to assess the association between statin intensity and postoperative major adverse events and in‐hospital mortality. Results Of 6497 patients undergoing open AAA repair, 3217 (49·5 per cent) received perioperative statin. Statin users were more likely to present with three or more co‐morbidities than non‐users (26·5 versus 21·8 per cent; P 
ISSN:2474-9842
2474-9842
DOI:10.1002/bjs5.94