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Antimicrobial Susceptibility of Pseudomonas aeruginosa to Ceftazidime-Avibactam, Ceftolozane-Tazobactam, Piperacillin-Tazobactam, and Meropenem Stratified by U.S. Census Divisions: Results from the 2017 INFORM Program

isolates ( = 1,909) were collected from 70 U.S. medical centers, and their susceptibilities were tested using the broth microdilution method. Ceftazidime-avibactam (MIC /MIC , 2/8 mg/liter) and ceftolozane-tazobactam (MIC /MIC , 0.5/2 mg/liter) were the most active (i.e., had the highest susceptibil...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2018-12, Vol.62 (12)
Main Authors: Sader, Helio S, Flamm, Robert K, Carvalhaes, Cecilia G, Castanheira, Mariana
Format: Article
Language:English
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Summary:isolates ( = 1,909) were collected from 70 U.S. medical centers, and their susceptibilities were tested using the broth microdilution method. Ceftazidime-avibactam (MIC /MIC , 2/8 mg/liter) and ceftolozane-tazobactam (MIC /MIC , 0.5/2 mg/liter) were the most active (i.e., had the highest susceptibility rates) compounds after colistin, with national susceptibility rates of 96.9% and 97.5%, respectively. Overall, piperacillin-tazobactam (MIC /MIC , 4/128 mg/liter) and meropenem (MIC /MIC , 0.5/16 mg/liter) were active against 77.5% and 76.0% of the isolates, respectively. Susceptibility variations across census divisions were documented for many antimicrobials.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01587-18