Evaluating tensile damage of brain tissue in intracerebral hemorrhage based on strain energy

Intracerebral hemorrhage (ICH) may lead to physical and pathological damage and has been a focus of research for decades. Evaluating tensile damage caused by deformation in ICH is an important component of damage assessment for correct diagnosis and treatment. Traditional research on ICH paid little...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2018-12, Vol.16 (6), p.4843-4852
Main Authors: Ren, Peng, Wang, Bo-Chu, Wang, Ya-Zhou, Hao, Shi-Lei, Guo, Ting-Wang, Li, Xiao-Fei
Format: Article
Language:English
Subjects:
Brain
Brain damage
Brain research
Energy
Experiments
Finite element method
Hemorrhage
Intracerebral hemorrhage
Mechanical properties
Medical examination
Methods
NMR
Nuclear magnetic resonance
Physiological aspects
Software
Studies
Tension tests
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Summary:Intracerebral hemorrhage (ICH) may lead to physical and pathological damage and has been a focus of research for decades. Evaluating tensile damage caused by deformation in ICH is an important component of damage assessment for correct diagnosis and treatment. Traditional research on ICH paid little attention to quantified brain tissue damage resulting from mechanical factors, and only a few reported the mechanical properties of damaged brain tissue. The aim of the present study was to present an effective method that is able to evaluate the tissue damage degree in ICH, based on strain energy function. Two finite element analysis (FEA) models were analyzed: A three-dimensional (3D) model for tissue's tension experiment and a two-dimensional (2D) model for brain tissue's deformation in ICH. The polynomial fitting function of stress vs. stretch curve, which was derived from previous reports, was used in the FEA as the constitutive function of brain tissue. The present study demonstrated that white matter could be regarded as hyperelastic material when stretch was 1.343. The strain energy loss was not linear in this process, and Neo-Hookean and Ogden model's results demonstrated a similar change in trend, but a difference in quantity. The results from 2D and 3D simulation, respectively, demonstrated the degree of damage according to the above dividing criteria and the possible distribution of tissue damage after ICH ictus. An analytical model from a biomechanical perspective for white matter injury in ICH may facilitate to improve clinical diagnosis and treatment.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.6757