Resveratrol protects against oxidative stress by activating the Keap-1/Nrf2 antioxidant defense system in obese-asthmatic rats

The aim of the present study was to investigate the potential mechanism underlying the anti-obesity-asthmatic effects of resveratrol (RSV) in a rat model of obese-asthma. Rat models of obesity and asthma were established using a high-fat diet and the administration of ovalbumin, respectively. Rats w...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2018-12, Vol.16 (6), p.4339-4348
Main Authors: Li, Xiao-Nan, Ma, Lu-Yi, Ji, Hong, Qin, Yuan-Hua, Jin, Shan-Shan, Xu, Li-Xin
Format: Article
Language:English
Subjects:
Albumin
Antioxidants (Nutrients)
Asthma
Blood glucose
Body weight
Calorimetry
Defense industry
Enzymes
Fasting
Glucose
Health aspects
Kinases
Laboratory rats
Obesity
Oxidative stress
Peroxidase
Reactive oxygen species
Resveratrol
Risk factors
Rodents
Studies
Superoxides
Triglycerides
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Summary:The aim of the present study was to investigate the potential mechanism underlying the anti-obesity-asthmatic effects of resveratrol (RSV) in a rat model of obese-asthma. Rat models of obesity and asthma were established using a high-fat diet and the administration of ovalbumin, respectively. Rats were divided into 7 different groups: A normal control, a normal obese, a normal asthma, a normal obese + asthma, a RSV obese, a RSV asthma and a RSV obese + asthma group. Body weight, Lee index, body fat and lung histopathological changes were evaluated. Serum lipid levels were evaluated using calorimetric methods. Levels of reactive oxygen species (ROS) were examined using enzyme-linked immunosorbent assays. Cellular antioxidant enzyme activities were measured using commercial kits. Levels of kelch-like ECH associated protein 1 (Keap-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) was examined using western blot analysis. The results indicated that obese and asthma rat models were successfully established. It was also demonstrated that RSV decreased fasting blood glucose in obese, asthmatic and obese-asthmatic rats. RSV altered serum lipid levels; it significantly increased high density lipoprotein cholesterol levels and significantly decreased serum triglyceride, serum total cholesterol and very low density lipoprotein levels, compared with untreated obese, asthmatic and obese-asthmatic rats (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.6747