Intima-media thickness of the common femoral artery as a marker of leg ulceration in sickle cell disease patients

Leg ulceration is a debilitating chronic complication of sickle cell disease (SCD) the pathogenesis of which is yet to be fully elucidated. We hypothesized that SCD patients with histories of previous leg ulcers would have intima hyperplasia of the common femoral artery (CFA). We enrolled 44 SCD pat...

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Published in:Blood advances 2018-11, Vol.2 (22), p.3112-3117
Main Authors: Ayoola, Oluwagbemiga O., Bolarinwa, Rahman A., Onakpoya, Uvie U., Adedeji, Tewogbade A., Onwuka, Chidiogo C., Idowu, Bukunmi M.
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Language:English
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Global Advances
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Summary:Leg ulceration is a debilitating chronic complication of sickle cell disease (SCD) the pathogenesis of which is yet to be fully elucidated. We hypothesized that SCD patients with histories of previous leg ulcers would have intima hyperplasia of the common femoral artery (CFA). We enrolled 44 SCD patients and 33 age-matched and sex-matched controls with hemoglobin AA. Anthropometric measurements, biochemical parameters, and sonographic intima-media thickness (IMT) of the CFA were determined. The median CFA IMT in SCD limbs with history of leg ulcers (SWLU) was 1.0 mm, whereas it was 0.7 mm in SCD limbs with no history of leg ulcer (SNLU) and 0.60 mm in controls (P < .001). Among the SNLU, 70.3% had CFA IMT
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2018023267