Combined Use of High-Sensitive Cardiac Troponin, Copeptin, and the Modified HEART Score for Rapid Evaluation of Chest Pain Patients

Background. Clinical short-term risk stratification is a recommended approach in patients with chest pain and possible acute myocardial infarction (AMI) to further improve high safety of biomarker-based rule-out algorithms. The study aim was to assess clinical performance of baseline concentrations...

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Bibliographic Details
Published in:Disease markers 2018-01, Vol.2018 (2018), p.1-7
Main Authors: Kawecki, Damian, Nowalany-Kozielska, Ewa, Tat, Lui Chun, Ho, Lam, Opara, Mariusz, Muzyk, Piotr, Przywara-Chowaniec, Brygida, Morawiec, Beata, Muller, Olivier
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Aged
Algorithms
Analysis
Biomarkers
Biomarkers - blood
Blood
Calcium-binding protein
Cardiology
Chest
Chest pain
Chest Pain - blood
Chest Pain - etiology
Chest Pain - mortality
Chest Pain - physiopathology
Cohort Studies
Cross-Sectional Studies
Diagnostic systems
EKG
Electrocardiogram
Electrocardiography
Emergency medical care
Emergency medical services
Emergency service
Emergency Service, Hospital
Ethylenediaminetetraacetic acid
Female
Glycopeptides - blood
Heart
Heart attack
Heart attacks
Hospitals
Humans
Laboratories
Male
Medical examination
Medical research
Medicine, Experimental
Middle Aged
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocardial Infarction - mortality
Pain
Patients
Predictive Value of Tests
Prognosis
Prospective Studies
Risk assessment
Sensitivity
Sensitivity analysis
Troponin
Troponin T
Troponin T - blood
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Summary:Background. Clinical short-term risk stratification is a recommended approach in patients with chest pain and possible acute myocardial infarction (AMI) to further improve high safety of biomarker-based rule-out algorithms. The study aim was to assess clinical performance of baseline concentrations of high-sensitivity cardiac troponin T (hs-TnT) and copeptin and the modified HEART score (mHS) in early presenters to the emergency department with chest pain. Methods. This cohort study included patients with chest pain with onset maximum of 6 h before admission and no persistent ST-segment elevation on electrocardiogram. hs-TnT, copeptin, and the mHS were assessed from admission data. The diagnostic and prognostic value for three baseline rule-out algorithms: (1) single hs-TnT 
ISSN:0278-0240
1875-8630
DOI:10.1155/2018/9136971