Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial

Background. Snakehead fish (Channa striatus) is a fresh water fish indigenous to many Asia countries and believed to have medical value. Studies showed that it contains all the essential amino acids and fatty acids able to accelerate wound healing and it has antinociceptive effect. However, little h...

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Published in:Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-9
Main Authors: Ali, Aishath Azna, Zahari, Arman, Zakaria, Zaidi, Zakaria, Andee Dzulkarnaen, Sani, Ikhwan, Ramely, Rosnelifaizur, Rao, Challa Venkata, Hayati, Firdaus, Sahid, Nik Amin, Hassan, Syed
Format: Article
Language:English
Subjects:
Amino acids
Antimicrobial agents
Care and treatment
Channa striata
Clinical trials
Evidence-based medicine
Fatty acids
Fish
Fresh water
Freshwater environments
Freshwater fish
Medical research
Nutrition
Pain
Pain perception
Pharmacology
Postoperative period
Randomization
Surgery
Variance analysis
Wound healing
Wounds and injuries
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Summary:Background. Snakehead fish (Channa striatus) is a fresh water fish indigenous to many Asia countries and believed to have medical value. Studies showed that it contains all the essential amino acids and fatty acids able to accelerate wound healing and it has antinociceptive effect. However, little human study has been done to assess the effectiveness of Channa striatus in wound healing. A prospective RCT has been conducted on the effect of Channa striatus spray versus placebo on clean wound to assess its pain control effect and cosmetic outcome. Methodology. One hundred and two patients (102) underwent clean elective surgery; postoperatively they were randomized into two group. One group received Channa striatus extract spray (n=51) another group received placebo (n=51) on daily basis for 2 weeks. They were followed up on 2nd, 4th, and 6th weeks. Pain control effect was assessed based on Visual Analog Pain Score (VAPS) and cosmetic outcome based on Visual Analog Cosmetic Scale (VACS), Wound Evaluation Scale (WES), and Vancouver Scar Scale (VSS). Result. The patient treated with Channa striatus spray displayed a better outcome in terms of pain control compared to placebo. During analysis using repeated measure ANOVA, there was significant difference of patient’s pain score based on VAPS between Channa striatus spray and placebo (F-stat (df) = 4.80 (2), p-value = 0.010). For cosmetic outcome it showed a better result in Channa striatus spray group for all the 3-scoring system, VACS, (F-stat (df) = 2.68 (2) , p-value
ISSN:1741-427X
1741-4288
DOI:10.1155/2018/3032790