Non-invasive quantification of tumor blood flow in prostate cancer using 15O-H2O PET/CT

• Published in: American journal of nuclear medicine and molecular imaging 2018-01, Vol.8 (5), p.292-302
• Main Authors: Tolbod, Lars P, Nielsen, Maria M, Pedersen, Bodil G, Høyer, Søren, Harms, Hendrik J, Borre, Michael, Borghammer, Per, Bouchelouche, Kirsten, Frøkiær, Jørgen, Sørensen, Jens
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 2160-8407; 2160-8407

Tumor blood flow (TBF) measurements in prostate cancer (PCa) provide an integrative index of tumor growth, which could be important for primary diagnosis and therapy response evaluation. 15 O-water PET is the non-invasive gold standard but is technically demanding. The aim of this study was to compare the accuracy of three different non-invasive strategies with an invasively measured arterial input function (BSIF): Using image-derived input functions (IDIF) from either 1) a separate heart scan or 2) the pelvic scan or 3) a populations-based input function (PBIF). Nine patients with biopsy-verified PCa scheduled for prostatectomy were included. All patients were characterized with serum levels of PSA (s-PSA), multiparametric magnetic resonance imaging (mpMRI) and post-surgical histopathology Gleason Grade. Dynamic 15 O-water was performed of the heart and the pelvic area 15 minutes apart. TBF estimated from both wash-in (K 1 ) and wash-out (k 2 ) constants was calculated using a one-compartmental model. Results: Mean (range) s-PSA was 12 (3-27) ng/mL, Gleason Grade Group was 2.9 (1-5), k 2 was 0.44 (0.007-1.2), and K 1 was 0.24 (0.07-0.55) mL/mL/min. k 2 (BSIF) correlated with s-PSA (r=0.86, P0.95, P0.95, P