C. elegans DLC-1 Associates with Ribonucleoprotein Complexes to Promote mRNA Regulation

Ribonucleoprotein complexes, which contain mRNAs and their regulator proteins, carry out post-transcriptional control of gene expression. The function of many RNA-binding proteins depends on their association with cofactors. Here, we use a genomic approach to identify transcripts associated with DLC...

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Bibliographic Details
Published in:FEBS letters 2018-10, Vol.592 (22), p.3683-3695
Main Authors: Day, Nicholas, Ellenbecker, Mary, Voronina, Ekaterina
Format: Article
Language:English
Online Access:Get full text
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Summary:Ribonucleoprotein complexes, which contain mRNAs and their regulator proteins, carry out post-transcriptional control of gene expression. The function of many RNA-binding proteins depends on their association with cofactors. Here, we use a genomic approach to identify transcripts associated with DLC-1, a protein previously identified as a cofactor of two unrelated RNA-binding proteins that act in the C. elegans germline. Among the 2732 potential DLC-1 targets, most are germline mRNAs associated with oogenesis. Removal of DLC-1 affects expression of its targets expressed in the oocytes, meg-1 and meg-3 . We propose that DLC-1 acts as a cofactor for multiple ribonucleoprotein complexes, including the ones regulating gene expression during oogenesis.
ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.13259