Prevalence of symptoms in glioma patients throughout the disease trajectory: a systematic review

Background Glioma patients suffer from a wide range of symptoms which influence quality of life negatively. The aim of this review is to give an overview of symptoms most prevalent in glioma patients throughout the total disease trajectory, to be used as a basis for the development of a specific gli...

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Bibliographic Details
Published in:Journal of neuro-oncology 2018-12, Vol.140 (3), p.485-496
Main Authors: IJzerman-Korevaar, Margriet, Snijders, Tom J., de Graeff, Alexander, Teunissen, Saskia C. C. M., de Vos, Filip Y. F.
Format: Article
Language:English
Subjects:
Aphasia
Brain Neoplasms - diagnosis
Brain Neoplasms - epidemiology
Central nervous system
Cognitive ability
Disease Progression
Drowsiness
Dysphagia
Dyspnea
Fatigue
Glioma
Glioma - diagnosis
Glioma - epidemiology
Headache
Humans
Medicine
Medicine & Public Health
Neurology
Oncology
Patients
Prevalence
Quality of Life
Respiration
Seizures
Spiders
Symptom Assessment
Systematic review
Topic Review
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Summary:Background Glioma patients suffer from a wide range of symptoms which influence quality of life negatively. The aim of this review is to give an overview of symptoms most prevalent in glioma patients throughout the total disease trajectory, to be used as a basis for the development of a specific glioma Patient Reported Outcome Measure (PROM) for early assessment and monitoring of symptoms in glioma patients. Methods A systematic review focused on symptom prevalence in glioma patients in different phases of disease and treatment was performed in MEDLINE, CINAHL and EMBASE according to PRISMA recommendations. We calculated weighted means for prevalence rates per symptom. Results The search identified 2.074 unique papers, of which 32 were included in this review. In total 25 symptoms were identified. The ten most prevalent symptoms were: seizures (37%), cognitive deficits (36%), drowsiness (35%), dysphagia (30%), headache (27%), confusion (27%), aphasia (24%), motor deficits (21%), fatigue (20%) and dyspnea (20%). Conclusions Eight out of ten of the most prevalent symptoms in glioma patients are related to the central nervous system and therefore specific for glioma. Our findings emphasize the importance of tailored symptom care for glioma patients and may aid in the development of specific PROMs for glioma patients in different phases of the disease.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-018-03015-9